› 1n4k

X-ray diffraction
2.2Å resolution

Crystal structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with IP3

Released:
DOI: 10.2210/pdb1n4k/pdb
PDB entry 1n4k coloured by chain, front view.
PDB entry 1n4k coloured by chain, side view.
PDB entry 1n4k coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand.
Bosanac I, Alattia JR, Mal TK, Chan J, Talarico S, Tong FK, Tong KI, Yoshikawa F, Furuichi T, Iwai M, Michikawa T, Mikoshiba K, Ikura M
Nature 420 696-700 (2002)
PMID: 12442173

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145968 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 Chain: A
Molecule details ›
Chain: A
Length: 381 amino acids
Theoretical weight: 43.6 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P11881 (Residues: 224-604; Coverage: 14%)
Gene names: Insp3r, Itpr1, Pcd6, Pcp1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand I3P 1 x I3P
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: C2221
Unit cell:
a: 44.101Å b: 90.42Å c: 207.117Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.224 0.248
Expression system: Escherichia coli

Quick links

Citations

55 review citations

Inositol trisphosphate receptor Ca2+ release channels.
Foskett et al. (2007)
54 more

31 mentions without citation

Analysis of protein-ligand interactions by fluorescence polarization.
Rossi et al. (2011)
30 more