PDBe 1mzf

X-ray diffraction
2.4Å resolution

Human Factor inhibiting HIF (FIH1) in Complex with 2-oxoglutarate

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hypoxia-inducible factor 1-alpha inhibitor Chain: A
Molecule details ›
Chain: A
Length: 351 amino acids
Theoretical weight: 40.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Best match: Q9NWT6 (Residues: 1-349)
Gene names: FIH1, HIF1AN

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P41212
Unit cell:
a: 86.46Å b: 86.46Å c: 147.81Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.235 0.232 0.244
Expression system: Escherichia coli