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Crystal Structure of a (Ca,Zn)-dependent alpha-amylase from the hyperthermophilic archaeon Pyrococcus woesei in complex with acarbose

Source organism: Pyrococcus woesei
Biochemical function: metal ion binding
Biological process: carbohydrate metabolic process
Cellular component: extracellular space

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EC 3.2.1.1: Alpha-amylase

Reaction catalysed:
Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units
Systematic name:
4-alpha-D-glucan glucanohydrolase
Alternative Name(s):
  • 1,4-alpha-D-glucan glucanohydrolase
  • Alpha amylase
  • Alpha-amylase
  • Endoamylase
  • Glycogenase
  • Taka-amylase A

GO terms

Sequence families

Pfam Protein families (Pfam)
PF09154
Domain description: Alpha-amylase C-terminal
Occurring in:
  1. Glycosyl hydrolase family 13 catalytic domain-containing protein
The deposited structure of PDB entry 1mxg contains 1 copy of Pfam domain PF09154 (Alpha-amylase C-terminal) in Glycosyl hydrolase family 13 catalytic domain-containing protein. Showing 1 copy in chain A.

PF00128
Domain description: Alpha amylase, catalytic domain
Occurring in:
  1. Glycosyl hydrolase family 13 catalytic domain-containing protein
The deposited structure of PDB entry 1mxg contains 1 copy of Pfam domain PF00128 (Alpha amylase, catalytic domain) in Glycosyl hydrolase family 13 catalytic domain-containing protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006046
Domain description: Alpha amylase
Occurring in:
  1. Glycosyl hydrolase family 13 catalytic domain-containing protein
IPR006047
Domain description: Glycosyl hydrolase, family 13, catalytic domain
Occurring in:
  1. Glycosyl hydrolase family 13 catalytic domain-containing protein
IPR015237
Domain description: Alpha-amylase C-terminal, prokaryotic
Occurring in:
  1. Glycosyl hydrolase family 13 catalytic domain-containing protein
IPR013780
Domain description: Glycosyl hydrolase, all-beta
Occurring in:
  1. Glycosyl hydrolase family 13 catalytic domain-containing protein
IPR017853
Domain description: Glycoside hydrolase superfamily
Occurring in:
  1. Glycosyl hydrolase family 13 catalytic domain-containing protein
IPR013776
Domain description: Alpha-amylase, thermostable
Occurring in:
  1. Glycosyl hydrolase family 13 catalytic domain-containing protein

Structure domains

CATH CATH domains
2.60.40.1180
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Golgi alpha-mannosidase II
Occurring in:
  1. Glycosyl hydrolase family 13 catalytic domain-containing protein
The deposited structure of PDB entry 1mxg contains 1 copy of CATH domain 2.60.40.1180 (Immunoglobulin-like) in Glycosyl hydrolase family 13 catalytic domain-containing protein. Showing 1 copy in chain A.
3.20.20.80
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Glycosidases
Occurring in:
  1. Glycosyl hydrolase family 13 catalytic domain-containing protein
The deposited structure of PDB entry 1mxg contains 1 copy of CATH domain 3.20.20.80 (TIM Barrel) in Glycosyl hydrolase family 13 catalytic domain-containing protein. Showing 1 copy in chain A.
SCOP SCOP annotations
51012
Class: All beta proteins
Fold: Glycosyl hydrolase domain
Superfamily: Glycosyl hydrolase domain
Occurring in:
  1. Glycosyl hydrolase family 13 catalytic domain-containing protein
The deposited structure of PDB entry 1mxg contains 1 copy of SCOP domain 51012 (alpha-Amylases, C-terminal beta-sheet domain) in Glycosyl hydrolase family 13 catalytic domain-containing protein. Showing 1 copy in chain A.
51446
Class: Alpha and beta proteins (a/b)
Fold: TIM beta/alpha-barrel
Superfamily: (Trans)glycosidases
Occurring in:
  1. Glycosyl hydrolase family 13 catalytic domain-containing protein
The deposited structure of PDB entry 1mxg contains 1 copy of SCOP domain 51446 (Amylase, catalytic domain) in Glycosyl hydrolase family 13 catalytic domain-containing protein. Showing 1 copy in chain A.

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