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Structure of F71N mutant of p18INK4c

X-ray diffraction
2.25Å resolution
PDB entry 1mx2 coloured by chain, front view.
PDB entry 1mx2 coloured by chain, side view.
PDB entry 1mx2 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cyclin-dependent kinase 4 inhibitor C
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Multimeric state: monomeric
Accessible surface area: 7958.25 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-154868
Assembly 2
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Assembly Name: Cyclin-dependent kinase 4 inhibitor C
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Multimeric state: monomeric
Accessible surface area: 8088.98 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-154868

Macromolecules

Cyclin-dependent kinase 4 inhibitor C
Chains: A, B
Length: 168 amino acids
Theoretical weight: 18.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P42773 (Residues: 1-168; Coverage: 100%)
Gene names: CDKN2C, CDKN6
Pfam: Ankyrin repeats (3 copies)
InterPro:
CATH: Ankyrin repeat-containing domain
SCOP: Ankyrin repeat
Cyclin-dependent kinase 4 inhibitor C in PDB entry 1mx2, assembly 1, front view.
Cyclin-dependent kinase 4 inhibitor C in PDB entry 1mx2, assembly 1, side view.
Cyclin-dependent kinase 4 inhibitor C in PDB entry 1mx2, assembly 1, top view.
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