PDBe 1mw4

Solution NMR

Solution structure of the human Grb7-SH2 domain in complex with a 10 amino acid peptide pY1139

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Growth factor receptor-bound protein 7 Chain: A
Molecule details ›
Chain: A
Length: 120 amino acids
Theoretical weight: 13.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14451 (Residues: 415-532; Coverage: 22%)
Gene name: GRB7
Sequence domains: SH2 domain
Structure domains: SHC Adaptor Protein
Receptor tyrosine-protein kinase erbB-2 Chain: B
Molecule details ›
Chain: B
Length: 10 amino acids
Theoretical weight: 1.27 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P04626 (Residues: 1135-1144; Coverage: 1%)
Gene names: ERBB2, HER2, MLN19, NEU, NGL

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression systems:
  • Escherichia coli
  • Not provided