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Crystal structure of the human RXR alpha ligand binding domain bound to the synthetic agonist compound BMS 649 and a coactivator peptide

Source organism: Homo sapiens
Biochemical function: zinc ion binding
Biological process: regulation of DNA-templated transcription
Cellular component: nucleus

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GO terms

Sequence family

Pfam Protein family (Pfam)
PF00104
Domain description: Ligand-binding domain of nuclear hormone receptor
Occurring in:
  1. Retinoic acid receptor RXR-alpha
The deposited structure of PDB entry 1mvc contains 1 copy of Pfam domain PF00104 (Ligand-binding domain of nuclear hormone receptor) in Retinoic acid receptor RXR-alpha. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001723
Domain description: Nuclear hormone receptor
Occurring in:
  1. Retinoic acid receptor RXR-alpha
IPR000003
Domain description: Retinoid X receptor/HNF4
Occurring in:
  1. Retinoic acid receptor RXR-alpha
IPR000536
Domain description: Nuclear hormone receptor, ligand-binding domain
Occurring in:
  1. Retinoic acid receptor RXR-alpha
IPR035500
Domain description: Nuclear hormone receptor-like domain superfamily
Occurring in:
  1. Retinoic acid receptor RXR-alpha

Structure domain

CATH CATH domain
1.10.565.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Retinoid X Receptor
Homology: Retinoid X Receptor
Occurring in:
  1. Retinoic acid receptor RXR-alpha
The deposited structure of PDB entry 1mvc contains 1 copy of CATH domain 1.10.565.10 (Retinoid X Receptor) in Retinoic acid receptor RXR-alpha. Showing 1 copy in chain A.
SCOP SCOP annotation
48509
Class: All alpha proteins
Fold: Nuclear receptor ligand-binding domain
Superfamily: Nuclear receptor ligand-binding domain
Occurring in:
  1. Retinoic acid receptor RXR-alpha
The deposited structure of PDB entry 1mvc contains 1 copy of SCOP domain 48509 (Nuclear receptor ligand-binding domain) in Retinoic acid receptor RXR-alpha. Showing 1 copy in chain A.

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