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G:T/U MISMATCH-SPECIFIC DNA GLYCOSYLASE FROM E.COLI

Source organism: Escherichia coli
Biochemical function: G/U mismatch-specific uracil-DNA glycosylase activity
Biological process: DNA damage response
Cellular component: cytoplasm

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EC 3.2.2.28: Double-stranded uracil-DNA glycosylase

Reaction catalysed:
Specifically hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free uracil
Systematic name:
Uracil-double-stranded DNA deoxyribohydrolase (uracil-releasing)
Alternative Name(s):
  • Double-strand uracil-DNA glycosylase
  • Double-stranded DNA specific UDG
  • DsDNA specific UDG
  • DsUDG
  • Dug
  • G:T/U mismatch-specific DNA glycosylase
  • Mug
  • UDG
  • UdgB

GO terms

Sequence family

Pfam Protein family (Pfam)
PF03167
Domain description: Uracil DNA glycosylase superfamily
Occurring in:
  1. G/U mismatch-specific DNA glycosylase
The deposited structure of PDB entry 1mug contains 1 copy of Pfam domain PF03167 (Uracil DNA glycosylase superfamily) in G/U mismatch-specific DNA glycosylase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR015637
Domain description: Uracil DNA glycosylase family 2
Occurring in:
  1. G/U mismatch-specific DNA glycosylase
IPR036895
Domain description: Uracil-DNA glycosylase-like domain superfamily
Occurring in:
  1. G/U mismatch-specific DNA glycosylase
IPR005122
Domain description: Uracil-DNA glycosylase-like
Occurring in:
  1. G/U mismatch-specific DNA glycosylase
IPR023502
Domain description: G/U mismatch-specific DNA glycosylase MUG, bacterial
Occurring in:
  1. G/U mismatch-specific DNA glycosylase

Structure domain

CATH CATH domain
3.40.470.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Uracil-DNA Glycosylase, subunit E
Homology: Uracil-DNA glycosylase-like domain
Occurring in:
  1. G/U mismatch-specific DNA glycosylase
The deposited structure of PDB entry 1mug contains 1 copy of CATH domain 3.40.470.10 (Uracil-DNA Glycosylase, subunit E) in G/U mismatch-specific DNA glycosylase. Showing 1 copy in chain A.
SCOP SCOP annotation
52147
Class: Alpha and beta proteins (a/b)
Fold: Uracil-DNA glycosylase-like
Superfamily: Uracil-DNA glycosylase-like
Occurring in:
  1. G/U mismatch-specific DNA glycosylase
The deposited structure of PDB entry 1mug contains 1 copy of SCOP domain 52147 (Mug-like) in G/U mismatch-specific DNA glycosylase. Showing 1 copy in chain A.

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