PDBe 1mqw

X-ray diffraction
2.3Å resolution

Structure of the MT-ADPRase in complex with three Mn2+ ions and AMPCPR, a Nudix enzyme

Released:

Function and Biology Details

Reaction catalysed:
ADP-D-ribose + H(2)O = AMP + D-ribose 5-phosphate. 
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
MutT/nudix family protein Chain: A
Molecule details ›
Chain: A
Length: 207 amino acids
Theoretical weight: 22.92 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: O33199 (Residues: 1-207; Coverage: 100%)
Gene name: MT1739
Sequence domains: NUDIX domain
Structure domains: Nucleoside Triphosphate Pyrophosphohydrolase

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P6122
Unit cell:
a: 64.078Å b: 64.078Å c: 182.887Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.205 0.205 0.266
Expression system: Escherichia coli