PDBe 1mox

X-ray diffraction
2.5Å resolution

Crystal Structure of Human Epidermal Growth Factor Receptor (residues 1-501) in complex with TGF-alpha

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Epidermal growth factor receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 501 amino acids
Theoretical weight: 55.69 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P00533 (Residues: 25-525; Coverage: 42%)
Gene names: EGFR, ERBB, ERBB1, HER1
Sequence domains:
Structure domains:
Transforming growth factor alpha Chains: C, D
Molecule details ›
Chains: C, D
Length: 50 amino acids
Theoretical weight: 5.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01135 (Residues: 40-89; Coverage: 37%)
Gene name: TGFA
Structure domains: Laminin

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P21
Unit cell:
a: 51.59Å b: 198.71Å c: 78.9Å
α: 90° β: 102.03° γ: 90°
R-values:
R R work R free
0.24 0.237 0.289
Expression systems:
  • Cricetulus griseus
  • Escherichia coli