› 1mm6

X-ray diffraction
2.15Å resolution

crystal structure of the GluR2 ligand binding core (S1S2J) in complex with quisqualate in a non zinc crystal form at 2.15 angstroms resolution

Released:
DOI: 10.2210/pdb1mm6/pdb
PDB entry 1mm6 coloured by chain, front view.
PDB entry 1mm6 coloured by chain, side view.
PDB entry 1mm6 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Mechanism of activation and selectivity in a ligand-gated ion channel: structural and functional studies of GluR2 and quisqualate.
Jin R, Horning M, Mayer ML, Gouaux E
Biochemistry 41 15635-43 (2002)
PMID: 12501192

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148607 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 263 amino acids
Theoretical weight: 29.22 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19491 (Residues: 413-527, 653-796; Coverage: 30%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

3 bound ligands:
Ligand SO4 3 x SO4
Ligand QUS 2 x QUS
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P21212
Unit cell:
a: 98.56Å b: 121.53Å c: 47.451Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.19 0.237
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

16 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
15 more

4 mentions without citation

Structure and mechanism of AMPA receptor - auxiliary protein complexes.
Chen et al. (2019)
3 more