› 1mim

X-ray diffraction
2.6Å resolution

IGG FAB FRAGMENT (CD25-BINDING)

Released:
DOI: 10.2210/pdb1mim/pdb
PDB entry 1mim coloured by chain, front view.
PDB entry 1mim coloured by chain, side view.
PDB entry 1mim coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the fab fragment of SDZ CHI621: a chimeric antibody against CD25.
Mikol V
Acta Crystallogr D Biol Crystallogr 52 534-42 (1996)
PMID: 15299676

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208541 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Immunoglobulin kappa constant Chain: L
Molecule details ›
Chain: L
Length: 210 amino acids
Theoretical weight: 22.88 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01834 (Residues: 1-106; Coverage: 99%)
Gene name: IGKC
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
CHIMERIC SDZ CHI621 Chain: H
Molecule details ›
Chain: H
Length: 215 amino acids
Theoretical weight: 23.14 KDa
Source organism: Homo sapiens
Expression system: Not provided
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 39.58Å b: 59.76Å c: 102.09Å
α: 90° β: 99.98° γ: 90°
R-values:
R R work R free
0.196 0.196 not available
Expression system: Not provided

Quick links

Citations

4 citation in other articles

Structural basis for the blockage of IL-2 signaling by therapeutic antibody basiliximab.
Du et al. (2010)
3 more

8 mentions without citation

Insufficiently dehydrated hydrogen bonds as determinants of protein interactions.
Fernández et al. (2003)
7 more