PDBe 1mem

X-ray diffraction
1.8Å resolution

Crystal structure of Cathepsin K complexed with a potent vinyl sulfone inhibitor

Source organism: Homo sapiens
Primary publication:
Crystal structure of human cathepsin K complexed with a potent inhibitor.
Nat. Struct. Biol. 4 105-9 (1997)
PMID: 9033587

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Cathepsin K Chain: A
Molecule details ›
Chain: A
Length: 215 amino acids
Theoretical weight: 23.52 KDa
Source organism: Homo sapiens
Expression system: Komagataella phaffii GS115
  • Best match: P43235 (Residues: 115-329)
Gene names: CTSK, CTSO, CTSO2

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P212121
Unit cell:
a: 40.82Å b: 50.04Å c: 105.92Å
α: 90° β: 90° γ: 90°
R R work R free
0.173 not available not available
Expression system: Komagataella phaffii GS115