› 1me7

X-ray diffraction
2.15Å resolution

Inosine Monophosphate Dehydrogenase (IMPDH) From Tritrichomonas Foetus with RVP and MOA bound

Released:
DOI: 10.2210/pdb1me7/pdb
PDB entry 1me7 coloured by chain, front view.
PDB entry 1me7 coloured by chain, side view.
PDB entry 1me7 coloured by chain, top view.
Source organism: Tritrichomonas suis
Primary publication:
Crystal structure of Tritrichomonas foetus inosine monophosphate dehydrogenase in complex with the inhibitor ribavirin monophosphate reveals a catalysis-dependent ion-binding site.
Prosise GL, Wu JZ, Luecke H
J Biol Chem 277 50654-9 (2002)
PMID: 12235158

Function and Biology Details

Reaction catalysed: 
Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156124 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inosine-5'-monophosphate dehydrogenase Chain: A
Molecule details ›
Chain: A
Length: 503 amino acids
Theoretical weight: 55.54 KDa
Source organism: Tritrichomonas suis
Expression system: Escherichia coli
UniProt:
  • Canonical: P50097 (Residues: 1-503; Coverage: 100%)
Gene name: IMPDH
Sequence domains:
Structure domains: Aldolase class I

Ligands and Environments

4 bound ligands:
Ligand NA 1 x NA
Ligand K 1 x K
Ligand RVP 1 x RVP
Ligand MOA 1 x MOA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: P432
Unit cell:
a: 155.068Å b: 155.068Å c: 155.068Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.233 0.264
Expression system: Escherichia coli

Quick links

Citations

4 review citations

IMP dehydrogenase: structure, mechanism, and inhibition.
Hedstrom L. (2009)
3 more

5 mentions without citation

Molecular mechanisms of SH2- and PTB-domain-containing proteins in receptor tyrosine kinase signaling.
Wagner et al. (2013)
4 more