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OXIDOREDUCTASE

Source organism: Escherichia coli
Biochemical function: FAD binding
Biological process: cell wall organization
Cellular component: cytosol

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EC 1.3.1.98: UDP-N-acetylmuramate dehydrogenase

Reaction catalysed:
UDP-N-acetyl-alpha-D-muramate + NADP(+) = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH
Systematic name:
UDP-N-acetyl-alpha-D-muramate:NADP(+) oxidoreductase
Alternative Name(s):
  • MurB reductase
  • UDP-GlcNAc-enoylpyruvate reductase
  • UDP-N-acetylenolpyruvoylglucosamine reductase
  • UDP-N-acetylglucosamine-enoylpyruvate reductase
  • Uridine diphospho-N-acetylglucosamine-enolpyruvate reductase
  • Uridine diphosphoacetylpyruvoylglucosamine reductase
  • Uridine-5'-diphospho-N-acetyl-2-amino-2-deoxy-3-O-lactylglucose:NADP-oxidoreductase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02873
Domain description: UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain
Occurring in:
  1. UDP-N-acetylenolpyruvoylglucosamine reductase
The deposited structure of PDB entry 1mbb contains 1 copy of Pfam domain PF02873 (UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain) in UDP-N-acetylenolpyruvoylglucosamine reductase. Showing 1 copy in chain A.

PF01565
Domain description: FAD binding domain
Occurring in:
  1. UDP-N-acetylenolpyruvoylglucosamine reductase
The deposited structure of PDB entry 1mbb contains 1 copy of Pfam domain PF01565 (FAD binding domain ) in UDP-N-acetylenolpyruvoylglucosamine reductase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003170
Domain description: UDP-N-acetylenolpyruvoylglucosamine reductase
Occurring in:
  1. UDP-N-acetylenolpyruvoylglucosamine reductase
IPR036635
Domain description: UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain superfamily
Occurring in:
  1. UDP-N-acetylenolpyruvoylglucosamine reductase
IPR011601
Domain description: UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal
Occurring in:
  1. UDP-N-acetylenolpyruvoylglucosamine reductase
IPR016169
Domain description: FAD-binding, type PCMH, subdomain 2
Occurring in:
  1. UDP-N-acetylenolpyruvoylglucosamine reductase
IPR006094
Domain description: FAD linked oxidase, N-terminal
Occurring in:
  1. UDP-N-acetylenolpyruvoylglucosamine reductase
IPR016166
Domain description: FAD-binding domain, PCMH-type
Occurring in:
  1. UDP-N-acetylenolpyruvoylglucosamine reductase
IPR036318
Domain description: FAD-binding, type PCMH-like superfamily
Occurring in:
  1. UDP-N-acetylenolpyruvoylglucosamine reductase
IPR016167
Domain description: FAD-binding, type PCMH, subdomain 1
Occurring in:
  1. UDP-N-acetylenolpyruvoylglucosamine reductase

Structure domains

CATH CATH domains
3.90.78.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 1
Homology: UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain
Occurring in:
  1. UDP-N-acetylenolpyruvoylglucosamine reductase
The deposited structure of PDB entry 1mbb contains 1 copy of CATH domain 3.90.78.10 (Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 1) in UDP-N-acetylenolpyruvoylglucosamine reductase. Showing 1 copy in chain A.
3.30.465.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3
Homology: Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3
Occurring in:
  1. UDP-N-acetylenolpyruvoylglucosamine reductase
The deposited structure of PDB entry 1mbb contains 1 copy of CATH domain 3.30.465.10 (Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3) in UDP-N-acetylenolpyruvoylglucosamine reductase. Showing 1 copy in chain A.
3.30.43.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2
Homology: Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2
Occurring in:
  1. UDP-N-acetylenolpyruvoylglucosamine reductase
The deposited structure of PDB entry 1mbb contains 1 copy of CATH domain 3.30.43.10 (Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2) in UDP-N-acetylenolpyruvoylglucosamine reductase. Showing 1 copy in chain A.
SCOP SCOP annotations
56195
Class: Alpha and beta proteins (a+b)
Fold: Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain
Superfamily: Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain
Occurring in:
  1. UDP-N-acetylenolpyruvoylglucosamine reductase
The deposited structure of PDB entry 1mbb contains 1 copy of SCOP domain 56195 (Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain) in UDP-N-acetylenolpyruvoylglucosamine reductase. Showing 1 copy in chain A.
56184
Class: Alpha and beta proteins (a+b)
Fold: FAD-binding/transporter-associated domain-like
Superfamily: FAD-binding/transporter-associated domain-like
Occurring in:
  1. UDP-N-acetylenolpyruvoylglucosamine reductase
The deposited structure of PDB entry 1mbb contains 1 copy of SCOP domain 56184 (Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase (MurB), N-terminal domain) in UDP-N-acetylenolpyruvoylglucosamine reductase. Showing 1 copy in chain A.

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