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Structure of a Sir2 enzyme bound to an acetylated p53 peptide

Source organisms:
Biochemical function: NAD+ binding
Biological process: not assigned
Cellular component: cytoplasm

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EC 2.3.1.286: Protein acetyllysine N-acetyltransferase

Reaction catalysed:
(1a) [protein]-N(6)-acetyl-L-lysine + NAD(+) = [protein]-N(6)-(1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl)-L-lysine + nicotinamide
Systematic name:
[Protein]-N(6)-acetyl-L-lysine:NAD(+) N-acetyltransferase (NAD(+)-hydrolyzing; 2''-O-acetyl-ADP-D-ribose-forming)
Alternative Name(s):
  • NAD(+)-dependent protein deacetylase
  • Protein lysine deacetylase
  • Sir2

GO terms

Sequence family

Pfam Protein family (Pfam)
PF02146
Domain description: Sir2 family
Occurring in:
  1. NAD-dependent protein deacylase 2
The deposited structure of PDB entry 1ma3 contains 1 copy of Pfam domain PF02146 (Sir2 family) in NAD-dependent protein deacylase 2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR026591
Domain description: Sirtuin, catalytic core small domain superfamily
Occurring in:
  1. NAD-dependent protein deacylase 2
IPR003000
Domain description: Sirtuin family
Occurring in:
  1. NAD-dependent protein deacylase 2
IPR027546
Domain description: Sirtuin, class III
Occurring in:
  1. NAD-dependent protein deacylase 2
IPR028628
Domain description: Sirtuin, class U
Occurring in:
  1. NAD-dependent protein deacylase 2
IPR029035
Domain description: DHS-like NAD/FAD-binding domain superfamily
Occurring in:
  1. NAD-dependent protein deacylase 2
IPR026590
Domain description: Sirtuin family, catalytic core domain
Occurring in:
  1. NAD-dependent protein deacylase 2

Structure domains

CATH CATH domains
3.40.50.1220
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: TPP-binding domain
Occurring in:
  1. NAD-dependent protein deacylase 2
The deposited structure of PDB entry 1ma3 contains 1 copy of CATH domain 3.40.50.1220 (Rossmann fold) in NAD-dependent protein deacylase 2. Showing 1 copy in chain A.
3.30.1600.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: SIR2/SIRT2 'Small Domain'
Homology: SIR2/SIRT2 'Small Domain'
Occurring in:
  1. NAD-dependent protein deacylase 2
The deposited structure of PDB entry 1ma3 contains 1 copy of CATH domain 3.30.1600.10 (SIR2/SIRT2 'Small Domain') in NAD-dependent protein deacylase 2. Showing 1 copy in chain A.
SCOP SCOP annotation
63984
Class: Alpha and beta proteins (a/b)
Fold: DHS-like NAD/FAD-binding domain
Superfamily: DHS-like NAD/FAD-binding domain
Occurring in:
  1. NAD-dependent protein deacylase 2
The deposited structure of PDB entry 1ma3 contains 1 copy of SCOP domain 63984 (Sir2 family of transcriptional regulators) in NAD-dependent protein deacylase 2. Showing 1 copy in chain A.

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