PDBe 1m9y

X-ray diffraction
1.9Å resolution

X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,G89A Complex.

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
HIV-1 Capsid Chains: C, D, G, H
Molecule details ›
Chains: C, D, G, H
Length: 146 amino acids
Theoretical weight: 16.15 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q72497 (Residues: 133-278; Coverage: 29%)
Gene name: gag
Structure domains: Human Immunodeficiency Virus Type 1 Capsid Protein
Peptidyl-prolyl cis-trans isomerase A Chains: A, B, E, F
Molecule details ›
Chains: A, B, E, F
Length: 165 amino acids
Theoretical weight: 18.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P62937 (Residues: 1-165; Coverage: 100%)
Gene names: CYPA, PPIA
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: P1
Unit cell:
a: 38.426Å b: 111.223Å c: 67.78Å
α: 89.99° β: 101.45° γ: 89.75°
R-values:
R R work R free
0.169 0.162 0.234
Expression system: Escherichia coli BL21(DE3)