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X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,A88M,G89A Complex.

Source organisms:
Biochemical function: heparan sulfate binding
Biological process: viral process
Cellular component: ficolin-1-rich granule lumen

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EC 5.2.1.8: Peptidylprolyl isomerase

Reaction catalysed:
Peptidylproline (omega=180) = peptidylproline (omega=0)
Systematic name:
Peptidylproline cis-trans-isomerase
Alternative Name(s):
  • Cyclophilin
  • PPIase
  • Peptide bond isomerase
  • Peptidyl-prolyl cis-trans isomerase
  • Peptidylprolyl cis-trans isomerase
  • Rotamase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00607
Domain description: gag protein p24 N-terminal domain
Occurring in:
  1. HIV-1 Capsid
The deposited structure of PDB entry 1m9x contains 4 copies of Pfam domain PF00607 (gag protein p24 N-terminal domain) in HIV-1 Capsid. Showing 1 copy in chain C.

PF00160
Domain description: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Occurring in:
  1. Peptidyl-prolyl cis-trans isomerase A
The deposited structure of PDB entry 1m9x contains 4 copies of Pfam domain PF00160 (Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD) in Peptidyl-prolyl cis-trans isomerase A. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002130
Domain description: Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
Occurring in:
  1. Peptidyl-prolyl cis-trans isomerase A
IPR029000
Domain description: Cyclophilin-like domain superfamily
Occurring in:
  1. Peptidyl-prolyl cis-trans isomerase A
IPR000721
Domain description: Retroviral nucleocapsid Gag protein p24, N-terminal
Occurring in:
  1. HIV-1 Capsid
IPR008919
Domain description: Retrovirus capsid, N-terminal
Occurring in:
  1. HIV-1 Capsid
IPR020892
Domain description: Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
Occurring in:
  1. Peptidyl-prolyl cis-trans isomerase A
IPR024936
Domain description: Cyclophilin-type peptidyl-prolyl cis-trans isomerase
Occurring in:
  1. Peptidyl-prolyl cis-trans isomerase A

Structure domains

CATH CATH domains
1.10.375.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Human Immunodeficiency Virus Type 1 Capsid Protein
Homology: Human Immunodeficiency Virus Type 1 Capsid Protein
Occurring in:
  1. HIV-1 Capsid
The deposited structure of PDB entry 1m9x contains 4 copies of CATH domain 1.10.375.10 (Human Immunodeficiency Virus Type 1 Capsid Protein) in HIV-1 Capsid. Showing 1 copy in chain C.
2.40.100.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Cyclophilin
Homology: Cyclophilin-like
Occurring in:
  1. Peptidyl-prolyl cis-trans isomerase A
The deposited structure of PDB entry 1m9x contains 4 copies of CATH domain 2.40.100.10 (Cyclophilin) in Peptidyl-prolyl cis-trans isomerase A. Showing 1 copy in chain A.
SCOP SCOP annotations
47944
Class: All alpha proteins
Fold: Retrovirus capsid protein, N-terminal core domain
Superfamily: Retrovirus capsid protein, N-terminal core domain
Occurring in:
  1. HIV-1 Capsid
The deposited structure of PDB entry 1m9x contains 4 copies of SCOP domain 47944 (Retrovirus capsid protein, N-terminal core domain) in HIV-1 Capsid. Showing 1 copy in chain C.
50892
Class: All beta proteins
Fold: Cyclophilin-like
Superfamily: Cyclophilin-like
Occurring in:
  1. Peptidyl-prolyl cis-trans isomerase A
The deposited structure of PDB entry 1m9x contains 4 copies of SCOP domain 50892 (Cyclophilin (peptidylprolyl isomerase)) in Peptidyl-prolyl cis-trans isomerase A. Showing 1 copy in chain A.

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