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Human Endothelial Nitric Oxide Synthase with 7-Nitroindazole Bound

X-ray diffraction
2.01Å resolution
PDB entry 1m9k coloured by chain, front view.
PDB entry 1m9k coloured by chain, side view.
PDB entry 1m9k coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Nitric oxide synthase 3
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Multimeric state: homo dimer
Accessible surface area: 32212.88 Å2
Buried surface area: 8869.39 Å2
Dissociation area: 2,726.93 Å2
Dissociation energy (ΔGdiss): 78.16 kcal/mol
Dissociation entropy (TΔSdiss): 14.47 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-151512

Macromolecules

Nitric oxide synthase 3
Chains: A, B
Length: 415 amino acids
Theoretical weight: 46.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P29474 (Residues: 67-481; Coverage: 35%)
Gene name: NOS3
Pfam: Nitric oxide synthase, oxygenase domain
InterPro:
CATH:
SCOP: Nitric oxide (NO) synthase oxygenase domain
Nitric oxide synthase 3 in PDB entry 1m9k, assembly 1, front view.
Nitric oxide synthase 3 in PDB entry 1m9k, assembly 1, side view.
Nitric oxide synthase 3 in PDB entry 1m9k, assembly 1, top view.
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