PDBe 1m9c

X-ray diffraction
2Å resolution

X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type Complex.

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
HIV-1 Capsid Chains: C, D
Molecule details ›
Chains: C, D
Length: 146 amino acids
Theoretical weight: 16.2 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q72497 (Residues: 133-278; Coverage: 29%)
Gene name: gag
Structure domains: Human Immunodeficiency Virus Type 1 Capsid Protein
Peptidyl-prolyl cis-trans isomerase A Chains: A, B
Molecule details ›
Chains: A, B
Length: 165 amino acids
Theoretical weight: 18.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P62937 (Residues: 1-165; Coverage: 100%)
Gene names: CYPA, PPIA
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: P21
Unit cell:
a: 38.445Å b: 113.235Å c: 67.006Å
α: 90° β: 100.53° γ: 90°
R-values:
R R work R free
0.201 0.195 0.259
Expression system: Escherichia coli BL21(DE3)