› › Function and Biology

Crystallographic Structure of SurA, a Molecular Chaperone that Facilitates Outer Membrane Porin Folding

Source organism: Escherichia coli
Biochemical function: unfolded protein binding
Biological process: chaperone-mediated protein folding
Cellular component: periplasmic space

Quick links

EC 5.2.1.8: Peptidylprolyl isomerase

Reaction catalysed:
Peptidylproline (omega=180) = peptidylproline (omega=0)
Systematic name:
Peptidylproline cis-trans-isomerase
Alternative Name(s):
  • Cyclophilin
  • PPIase
  • Peptide bond isomerase
  • Peptidyl-prolyl cis-trans isomerase
  • Peptidylprolyl cis-trans isomerase
  • Rotamase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF13616
Domain description: PPIC-type PPIASE domain
Occurring in:
  1. Chaperone SurA
The deposited structure of PDB entry 1m5y contains 4 copies of Pfam domain PF13616 (PPIC-type PPIASE domain) in Chaperone SurA. Showing 1 copy in chain D.

PF00639
Domain description: PPIC-type PPIASE domain
Occurring in:
  1. Chaperone SurA
The deposited structure of PDB entry 1m5y contains 4 copies of Pfam domain PF00639 (PPIC-type PPIASE domain) in Chaperone SurA. Showing 1 copy in chain D.

PF09312
Domain description: SurA N-terminal domain
Occurring in:
  1. Chaperone SurA
The deposited structure of PDB entry 1m5y contains 4 copies of Pfam domain PF09312 (SurA N-terminal domain) in Chaperone SurA. Showing 1 copy in chain D.

InterPro InterPro annotations
IPR000297
Domain description: Peptidyl-prolyl cis-trans isomerase, PpiC-type
Occurring in:
  1. Chaperone SurA
IPR046357
Domain description: Peptidyl-prolyl cis-trans isomerase domain superfamily
Occurring in:
  1. Chaperone SurA
IPR023058
Domain description: Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site
Occurring in:
  1. Chaperone SurA
IPR027304
Domain description: Trigger factor/SurA domain superfamily
Occurring in:
  1. Chaperone SurA
IPR015391
Domain description: SurA N-terminal
Occurring in:
  1. Chaperone SurA
IPR023034
Domain description: Peptidyl-prolyl isomerase SurA
Occurring in:
  1. Chaperone SurA

Structure domains

CATH CATH domains
3.10.50.40
Class: Alpha Beta
Architecture: Roll
Topology: Chitinase A; domain 3
Homology: Chitinase A; domain 3
Occurring in:
  1. Chaperone SurA
The deposited structure of PDB entry 1m5y contains 8 copies of CATH domain 3.10.50.40 (Chitinase A; domain 3) in Chaperone SurA. Showing 2 copies in chain D.
1.10.4030.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Triger factor/SurA peptide-binding fold
Homology: Porin chaperone SurA, peptide-binding domain
Occurring in:
  1. Chaperone SurA
The deposited structure of PDB entry 1m5y contains 4 copies of CATH domain 1.10.4030.10 (Triger factor/SurA peptide-binding fold) in Chaperone SurA. Showing 1 copy in chain D.
SCOP SCOP annotations
54535
Class: Alpha and beta proteins (a+b)
Fold: FKBP-like
Superfamily: FKBP-like
Occurring in:
  1. Chaperone SurA
The deposited structure of PDB entry 1m5y contains 8 copies of SCOP domain 54535 (FKBP immunophilin/proline isomerase) in Chaperone SurA. Showing 2 copies in chain D.
81828
Class: All alpha proteins
Fold: Triger factor/SurA peptide-binding domain-like
Superfamily: Triger factor/SurA peptide-binding domain-like
Occurring in:
  1. Chaperone SurA
The deposited structure of PDB entry 1m5y contains 4 copies of SCOP domain 81828 (Porin chaperone SurA, peptide-binding domain) in Chaperone SurA. Showing 1 copy in chain D.

Quick links