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CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHA VBETA3 BOUND TO MN2+

Source organism: Homo sapiens
Biochemical function: extracellular matrix binding
Biological process: negative regulation of low-density lipoprotein receptor activity
Cellular component: anchoring junction

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GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF01839
Domain description: FG-GAP repeat
Occurring in:
  1. Integrin alpha-V
The deposited structure of PDB entry 1m1x contains 3 copies of Pfam domain PF01839 (FG-GAP repeat) in Integrin alpha-V. Showing 3 copies in chain A.

PF07965
Domain description: Integrin beta tail domain
Occurring in:
  1. Integrin beta-3
The deposited structure of PDB entry 1m1x contains 1 copy of Pfam domain PF07965 (Integrin beta tail domain) in Integrin beta-3. Showing 1 copy in chain B.

PF07974
Domain description: EGF-like domain
Occurring in:
  1. Integrin beta-3
The deposited structure of PDB entry 1m1x contains 1 copy of Pfam domain PF07974 (EGF-like domain) in Integrin beta-3. Showing 1 copy in chain B.

PF18372
Domain description: Integrin beta epidermal growth factor like domain 1
Occurring in:
  1. Integrin beta-3
The deposited structure of PDB entry 1m1x contains 1 copy of Pfam domain PF18372 (Integrin beta epidermal growth factor like domain 1) in Integrin beta-3. Showing 1 copy in chain B (this domain is out of the observed residue ranges!).

PF00362
Domain description: Integrin beta chain VWA domain
Occurring in:
  1. Integrin beta-3
The deposited structure of PDB entry 1m1x contains 1 copy of Pfam domain PF00362 (Integrin beta chain VWA domain) in Integrin beta-3. Showing 1 copy in chain B.

PF17205
Domain description: Integrin plexin domain
Occurring in:
  1. Integrin beta-3
The deposited structure of PDB entry 1m1x contains 1 copy of Pfam domain PF17205 (Integrin plexin domain) in Integrin beta-3. Showing 1 copy in chain B (this domain is out of the observed residue ranges!).

PF20806
Domain description: Integrin alpha Ig-like domain 3
Occurring in:
  1. Integrin alpha-V

PF20805
Domain description: Integrin alpha Ig-like domain 2
Occurring in:
  1. Integrin alpha-V

PF08441
Domain description: Integrin alpha Ig-like domain 1
Occurring in:
  1. Integrin alpha-V
The deposited structure of PDB entry 1m1x contains 1 copy of Pfam domain PF08441 (Integrin alpha) in Integrin alpha-V. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR015812
Domain description: Integrin beta subunit
Occurring in:
  1. Integrin beta-3
IPR013519
Domain description: Integrin alpha beta-propellor
Occurring in:
  1. Integrin alpha-V
IPR000413
Domain description: Integrin alpha chain
Occurring in:
  1. Integrin alpha-V
IPR032695
Domain description: Integrin domain superfamily
Occurring in:
  1. Integrin alpha-V
  2. Integrin beta-3
IPR013517
Domain description: FG-GAP repeat
Occurring in:
  1. Integrin alpha-V
IPR012896
Domain description: Integrin beta subunit, tail
Occurring in:
  1. Integrin beta-3
IPR036465
Domain description: von Willebrand factor A-like domain superfamily
Occurring in:
  1. Integrin beta-3
IPR002369
Domain description: Integrin beta subunit, VWA domain
Occurring in:
  1. Integrin beta-3
IPR036349
Domain description: Integrin beta tail domain superfamily
Occurring in:
  1. Integrin beta-3
IPR013111
Domain description: EGF-like domain, extracellular
Occurring in:
  1. Integrin beta-3
IPR040622
Domain description: Integrin beta, epidermal growth factor-like domain 1
Occurring in:
  1. Integrin beta-3
IPR016201
Domain description: PSI domain
Occurring in:
  1. Integrin beta-3
IPR033760
Domain description: Integrin beta N-terminal
Occurring in:
  1. Integrin beta-3
IPR013649
Domain description: Integrin alpha, first immunoglubulin-like domain
Occurring in:
  1. Integrin alpha-V
IPR028994
Domain description: Integrin alpha, N-terminal
Occurring in:
  1. Integrin alpha-V

Structure domains

CATH CATH domains
2.60.40.1510
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: ntegrin, alpha v. Chain A, domain 3
Occurring in:
  1. Integrin alpha-V
  2. Integrin beta-3
The deposited structure of PDB entry 1m1x contains 1 copy of CATH domain 2.60.40.1510 (Immunoglobulin-like) in Integrin alpha-V. Showing 1 copy in chain A.
The deposited structure of PDB entry 1m1x contains 1 copy of CATH domain 2.60.40.1510 (Immunoglobulin-like) in Integrin beta-3. Showing 1 copy in chain B.
4.10.1240.30
Class: Few Secondary Structures
Architecture: Irregular
Topology: Hormone receptor fold
Homology: Hormone receptor fold
Occurring in:
  1. Integrin beta-3
The deposited structure of PDB entry 1m1x contains 1 copy of CATH domain 4.10.1240.30 (Hormone receptor fold) in Integrin beta-3. Showing 1 copy in chain B.
2.10.25.10
Class: Mainly Beta
Architecture: Ribbon
Topology: Laminin
Homology: Laminin
Occurring in:
  1. Integrin beta-3
The deposited structure of PDB entry 1m1x contains 1 copy of CATH domain 2.10.25.10 (Laminin) in Integrin beta-3. Showing 1 copy in chain B.
3.40.50.410
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: von Willebrand factor, type A domain
Occurring in:
  1. Integrin beta-3
The deposited structure of PDB entry 1m1x contains 1 copy of CATH domain 3.40.50.410 (Rossmann fold) in Integrin beta-3. Showing 1 copy in chain B.
2.60.40.1530
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: ntegrin, alpha v. Chain A, domain 4
Occurring in:
  1. Integrin alpha-V
The deposited structure of PDB entry 1m1x contains 1 copy of CATH domain 2.60.40.1530 (Immunoglobulin-like) in Integrin alpha-V. Showing 1 copy in chain A.
2.60.40.1460
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Integrin domains. Chain A, domain 2
Occurring in:
  1. Integrin alpha-V
The deposited structure of PDB entry 1m1x contains 1 copy of CATH domain 2.60.40.1460 (Immunoglobulin-like) in Integrin alpha-V. Showing 1 copy in chain A.
2.130.10.130
Class: Mainly Beta
Architecture: 7 Propeller
Topology: Methylamine Dehydrogenase; Chain H
Homology: Integrin alpha, N-terminal
Occurring in:
  1. Integrin alpha-V
The deposited structure of PDB entry 1m1x contains 1 copy of CATH domain 2.130.10.130 (Methylamine Dehydrogenase; Chain H) in Integrin alpha-V. Showing 1 copy in chain A.
SCOP SCOP annotations
69180
Class: All beta proteins
Fold: Immunoglobulin-like beta-sandwich
Superfamily: Integrin domains
Occurring in:
  1. Integrin alpha-V
  2. Integrin beta-3
The deposited structure of PDB entry 1m1x contains 3 copies of SCOP domain 69180 (Integrin domains) in Integrin alpha-V. Showing 3 copies in chain A.
The deposited structure of PDB entry 1m1x contains 1 copy of SCOP domain 69180 (Integrin domains) in Integrin beta-3. Showing 1 copy in chain B.
69940
Class: Small proteins
Fold: Knottins (small inhibitors, toxins, lectins)
Superfamily: EGF/Laminin
Occurring in:
  1. Integrin beta-3
The deposited structure of PDB entry 1m1x contains 2 copies of SCOP domain 69940 (Integrin beta EGF-like domains) in Integrin beta-3. Showing 2 copies in chain B.
69688
Class: Alpha and beta proteins (a+b)
Fold: Integrin beta tail domain
Superfamily: Integrin beta tail domain
Occurring in:
  1. Integrin beta-3
The deposited structure of PDB entry 1m1x contains 1 copy of SCOP domain 69688 (Integrin beta tail domain) in Integrin beta-3. Showing 1 copy in chain B.
53301
Class: Alpha and beta proteins (a/b)
Fold: vWA-like
Superfamily: vWA-like
Occurring in:
  1. Integrin beta-3
The deposited structure of PDB entry 1m1x contains 1 copy of SCOP domain 53301 (Integrin A (or I) domain) in Integrin beta-3. Showing 1 copy in chain B.
69319
Class: All beta proteins
Fold: 7-bladed beta-propeller
Superfamily: Integrin alpha N-terminal domain
Occurring in:
  1. Integrin alpha-V
The deposited structure of PDB entry 1m1x contains 1 copy of SCOP domain 69319 (Integrin alpha N-terminal domain) in Integrin alpha-V. Showing 1 copy in chain A.

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