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CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHA VBETA3 BOUND TO MN2+

X-ray diffraction
3.3Å resolution
PDB entry 1m1x coloured by chain, front view.
PDB entry 1m1x coloured by chain, side view.
PDB entry 1m1x coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Integrin alphav-beta3 complex
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Multimeric state: hetero dimer
Accessible surface area: 64834.41 Å2
Buried surface area: 11424.69 Å2
Dissociation area: 3,010.9 Å2
Dissociation energy (ΔGdiss): 12.46 kcal/mol
Dissociation entropy (TΔSdiss): 15.98 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138434
Complex Portal ID: CPX-1795

Macromolecules

Integrin alpha-V
Chain: A
Length: 957 amino acids
Theoretical weight: 105.88 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P06756 (Residues: 31-987; Coverage: 94%)
Gene names: ITGAV, MSK8, VNRA, VTNR
Pfam:
InterPro:
CATH:
SCOP:
Integrin alpha-V in PDB entry 1m1x, assembly 1, front view.
Integrin alpha-V in PDB entry 1m1x, assembly 1, side view.
Integrin alpha-V in PDB entry 1m1x, assembly 1, top view.
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Integrin beta-3
Chain: B
Length: 692 amino acids
Theoretical weight: 76.65 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P05106 (Residues: 27-718; Coverage: 91%)
Gene names: GP3A, ITGB3
Pfam:
InterPro:
CATH:
SCOP:
Integrin beta-3 in PDB entry 1m1x, assembly 1, front view.
Integrin beta-3 in PDB entry 1m1x, assembly 1, side view.
Integrin beta-3 in PDB entry 1m1x, assembly 1, top view.
Molecule details ›

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