Reviews - 1lxf mentioned but not cited (1)
- Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs. Li MX, Hwang PM. Gene 571 153-166 (2015)
Articles - 1lxf mentioned but not cited (16)
- A structural and functional perspective into the mechanism of Ca2+-sensitizers that target the cardiac troponin complex. Robertson IM, Sun YB, Li MX, Sykes BD. J Mol Cell Cardiol 49 1031-1041 (2010)
- The overlap of small molecule and protein binding sites within families of protein structures. Davis FP, Sali A. PLoS Comput Biol 6 e1000668 (2010)
- Two structural motifs within canonical EF-hand calcium-binding domains identify five different classes of calcium buffers and sensors. Denessiouk K, Permyakov S, Denesyuk A, Permyakov E, Johnson MS. PLoS One 9 e109287 (2014)
- Molecular basis of calcium-sensitizing and desensitizing mutations of the human cardiac troponin C regulatory domain: a multi-scale simulation study. Kekenes-Huskey PM, Lindert S, McCammon JA. PLoS Comput Biol 8 e1002777 (2012)
- Solution structure of the regulatory domain of human cardiac troponin C in complex with the switch region of cardiac troponin I and W7: the basis of W7 as an inhibitor of cardiac muscle contraction. Oleszczuk M, Robertson IM, Li MX, Sykes BD. J Mol Cell Cardiol 48 925-933 (2010)
- A computational and experimental approach to investigate bepridil binding with cardiac troponin. Varughese JF, Baxley T, Chalovich JM, Li Y. J Phys Chem B 115 2392-2400 (2011)
- Structure of the inhibitor W7 bound to the regulatory domain of cardiac troponin C. Hoffman RM, Sykes BD. Biochemistry 48 5541-5552 (2009)
- Structural and functional impact of troponin C-mediated Ca2+ sensitization on myofilament lattice spacing and cross-bridge mechanics in mouse cardiac muscle. Gonzalez-Martinez D, Johnston JR, Landim-Vieira M, Ma W, Antipova O, Awan O, Irving TC, Bryant Chase P, Pinto JR. J Mol Cell Cardiol 123 26-37 (2018)
- Successful Identification of Cardiac Troponin Calcium Sensitizers Using a Combination of Virtual Screening and ROC Analysis of Known Troponin C Binders. Aprahamian ML, Tikunova SB, Price MV, Cuesta AF, Davis JP, Lindert S. J Chem Inf Model 57 3056-3069 (2017)
- Mechanism of Cardiac Troponin C Calcium Sensitivity Modulation by Small Molecules Illuminated by Umbrella Sampling Simulations. Bowman JD, Coldren WH, Lindert S. J Chem Inf Model 59 2964-2972 (2019)
- Searching for bioactive conformations of drug-like ligands with current force fields: how good are we? Gürsoy O, Smieško M. J Cheminform 9 29 (2017)
- Computing the protein binding sites. Guo F, Wang L. BMC Bioinformatics 13 Suppl 10 S2 (2012)
- Discovery of Novel Small-Molecule Calcium Sensitizers for Cardiac Troponin C: A Combined Virtual and Experimental Screening Approach. Coldren WH, Tikunova SB, Davis JP, Lindert S. J Chem Inf Model 60 3648-3661 (2020)
- The effect of the cosolvent trifluoroethanol on a tryptophan side chain orientation in the hydrophobic core of troponin C. Julien O, Mercier P, Crane ML, Sykes BD. Protein Sci 18 1165-1174 (2009)
- Accurate Representation of Protein-Ligand Structural Diversity in the Protein Data Bank (PDB). Shinada NK, Schmidtke P, de Brevern AG. Int J Mol Sci 21 E2243 (2020)
- research-article Targeting Troponin C with Small Molecules Containing Diphenyl Moieties: Calcium Sensitivity Effects on Striated Muscle and Structure Activity Relationship. Hantz ER, Tikunova SB, Belevych N, Davis JP, Reiser PJ, Lindert S. bioRxiv 2023.02.06.527323 (2023)
Reviews citing this publication (7)
- Structural based insights into the role of troponin in cardiac muscle pathophysiology. Li MX, Wang X, Sykes BD. J Muscle Res Cell Motil 25 559-579 (2004)
- The contractile apparatus as a target for drugs against heart failure: interaction of levosimendan, a calcium sensitiser, with cardiac troponin c. Sorsa T, Pollesello P, Solaro RJ. Mol Cell Biochem 266 87-107 (2004)
- Targeting the sarcomere to correct muscle function. Hwang PM, Sykes BD. Nat Rev Drug Discov 14 313-328 (2015)
- Interaction of cardiac troponin with cardiotonic drugs: a structural perspective. Li MX, Robertson IM, Sykes BD. Biochem Biophys Res Commun 369 88-99 (2008)
- Cardiac Troponin and Tropomyosin: Structural and Cellular Perspectives to Unveil the Hypertrophic Cardiomyopathy Phenotype. Marques MA, de Oliveira GA. Front Physiol 7 429 (2016)
- Structures reveal details of small molecule binding to cardiac troponin. Cai F, Li MX, Pineda-Sanabria SE, Gelozia S, Lindert S, West F, Sykes BD, Hwang PM. J Mol Cell Cardiol 101 134-144 (2016)
- Significance of Cardiac Troponins as an Identification Tool in COVID-19 Patients Using Biosensors: An Update. Rasmi Y, Mosa OF, Alipour S, Heidari N, Javanmard F, Golchin A, Gholizadeh-Ghaleh Aziz S. Front Mol Biosci 9 821155 (2022)
Articles citing this publication (33)
- Preformed structural elements feature in partner recognition by intrinsically unstructured proteins. Fuxreiter M, Simon I, Friedrich P, Tompa P. J Mol Biol 338 1015-1026 (2004)
- Ca(2+)-regulated structural changes in troponin. Vinogradova MV, Stone DB, Malanina GG, Karatzaferi C, Cooke R, Mendelson RA, Fletterick RJ. Proc Natl Acad Sci U S A 102 5038-5043 (2005)
- Single mutation (A162H) in human cardiac troponin I corrects acid pH sensitivity of Ca2+-regulated actomyosin S1 ATPase. Dargis R, Pearlstone JR, Barrette-Ng I, Edwards H, Smillie LB. J Biol Chem 277 34662-34665 (2002)
- Thin filament Ca2+ binding properties and regulatory unit interactions alter kinetics of tension development and relaxation in rabbit skeletal muscle. Kreutziger KL, Piroddi N, Scellini B, Tesi C, Poggesi C, Regnier M. J Physiol 586 3683-3700 (2008)
- Dynamics and calcium association to the N-terminal regulatory domain of human cardiac troponin C: a multiscale computational study. Lindert S, Kekenes-Huskey PM, Huber G, Pierce L, McCammon JA. J Phys Chem B 116 8449-8459 (2012)
- Structure and dynamics of the C-domain of human cardiac troponin C in complex with the inhibitory region of human cardiac troponin I. Lindhout DA, Sykes BD. J Biol Chem 278 27024-27034 (2003)
- Long-timescale molecular dynamics simulations elucidate the dynamics and kinetics of exposure of the hydrophobic patch in troponin C. Lindert S, Kekenes-Huskey PM, McCammon JA. Biophys J 103 1784-1789 (2012)
- Calcium-dependent changes in the flexibility of the regulatory domain of troponin C in the troponin complex. Blumenschein TM, Stone DB, Fletterick RJ, Mendelson RA, Sykes BD. J Biol Chem 280 21924-21932 (2005)
- Conformational changes of troponin C within the thin filaments detected by neutron scattering. Matsumoto F, Makino K, Maeda K, Patzelt H, Maéda Y, Fujiwara S. J Mol Biol 342 1209-1221 (2004)
- Defining the binding site of levosimendan and its analogues in a regulatory cardiac troponin C-troponin I complex. Robertson IM, Baryshnikova OK, Li MX, Sykes BD. Biochemistry 47 7485-7495 (2008)
- Amide hydrogens reveal a temperature-dependent structural transition that enhances site-II Ca2+-binding affinity in a C-domain mutant of cardiac troponin C. Veltri T, de Oliveira GAP, Bienkiewicz EA, Palhano FL, Marques MA, Moraes AH, Silva JL, Sorenson MM, Pinto JR. Sci Rep 7 691 (2017)
- Calcium structural transition of human cardiac troponin C in reconstituted muscle fibres as studied by site-directed spin labelling. Nakamura M, Ueki S, Hara H, Arata T. J Mol Biol 348 127-137 (2005)
- Molecular Effects of cTnC DCM Mutations on Calcium Sensitivity and Myofilament Activation-An Integrated Multiscale Modeling Study. Dewan S, McCabe KJ, Regnier M, McCulloch AD, Lindert S. J Phys Chem B 120 8264-8275 (2016)
- Molecular dynamics and docking studies on cardiac troponin C. Varguhese JF, Li Y. J Biomol Struct Dyn 29 123-135 (2011)
- Nuclear magnetic resonance structure of calcium-binding protein 1 in a Ca(2+) -bound closed state: implications for target recognition. Park S, Li C, Ames JB. Protein Sci 20 1356-1366 (2011)
- Visualizing the principal component of ¹H, ¹⁵N-HSQC NMR spectral changes that reflect protein structural or functional properties: application to troponin C. Robertson IM, Boyko RF, Sykes BD. J Biomol NMR 51 115-122 (2011)
- Probing the mechanism of cardiovascular drugs using a covalent levosimendan analog. Pineda-Sanabria SE, Robertson IM, Sun YB, Irving M, Sykes BD. J Mol Cell Cardiol 92 174-184 (2016)
- Fluorescence Based Characterization of Calcium Sensitizer Action on the Troponin Complex. Schlecht W, Li KL, Hu D, Dong W. Chem Biol Drug Des 87 171-181 (2016)
- Molecular characterization and immunohistochemical localization of a novel troponin C during silkworm development. Chen J, Chen J, Gai Q, Lv Z, Wang D, Nie Z, Wang J, Wang X, Wu X, Zhang Y. Cell Tissue Res 331 725-738 (2008)
- NanoMEA: A Tool for High-Throughput, Electrophysiological Phenotyping of Patterned Excitable Cells. Smith AST, Choi E, Gray K, Macadangdang J, Ahn EH, Clark EC, Laflamme MA, Wu JC, Murry CE, Tung L, Kim DH. Nano Lett 20 1561-1570 (2020)
- The structure of cardiac troponin C regulatory domain with bound Cd2+ reveals a closed conformation and unique ion coordination. Zhang XL, Tibbits GF, Paetzel M. Acta Crystallogr D Biol Crystallogr 69 722-734 (2013)
- A comprehensive guide to genetic variants and post-translational modifications of cardiac troponin C. Reinoso TR, Landim-Vieira M, Shi Y, Johnston JR, Chase PB, Parvatiyar MS, Landstrom AP, Pinto JR, Tadros HJ. J Muscle Res Cell Motil 42 323-342 (2021)
- 3-Chlorodiphenylamine activates cardiac troponin by a mechanism distinct from bepridil or TFP. Tikunova SB, Cuesta A, Price M, Li MX, Belevych N, Biesiadecki BJ, Reiser PJ, Hwang PM, Davis JP. J Gen Physiol 151 9-17 (2019)
- Crystal structure of cardiac troponin C regulatory domain in complex with cadmium and deoxycholic acid reveals novel conformation. Li AY, Lee J, Borek D, Otwinowski Z, Tibbits GF, Paetzel M. J Mol Biol 413 699-711 (2011)
- Proof of Principle that Molecular Modeling Followed by a Biophysical Experiment Can Develop Small Molecules that Restore Function to the Cardiac Thin Filament in the Presence of Cardiomyopathic Mutations. Szatkowski L, Lynn ML, Holeman T, Williams MR, Baldo AP, Tardiff JC, Schwartz SD. ACS Omega 4 6492-6501 (2019)
- Conformation of the critical pH sensitive region of troponin depends upon a single residue in troponin I. Robertson IM, Pineda-Sanabria SE, Holmes PC, Sykes BD. Arch Biochem Biophys 552-553 40-49 (2014)
- 1H, 15N, and 13C chemical shift assignments of calcium-binding protein 1 with Ca2+ bound at EF1, EF3 and EF4. Park S, Li C, Ames JB. Biomol NMR Assign 4 159-161 (2010)
- Targeting Troponin C with Small Molecules Containing Diphenyl Moieties: Calcium Sensitivity Effects on Striated Muscles and Structure-Activity Relationship. Hantz ER, Tikunova SB, Belevych N, Davis JP, Reiser PJ, Lindert S. J Chem Inf Model 63 3462-3473 (2023)
- The calcium sensitizer drug MCI-154 binds the structural C-terminal domain of cardiac troponin C. Li MX, Gelozia S, Danmaliki GI, Wen Y, Liu PB, Lemieux MJ, West FG, Sykes BD, Hwang PM. Biochem Biophys Rep 16 145-151 (2018)
- Computational Methods Elucidate Consequences of Mutations and Post-translational Modifications on Troponin I Effective Concentration to Troponin C. Cool AM, Lindert S. J Phys Chem B 125 7388-7396 (2021)
- Conversion of a Cardiac Muscle Modulator from an Inhibitor to an Activator. Cai F, Kampourakis T, Parijat P, Cockburn KT, Sykes BD. ACS Med Chem Lett 14 530-533 (2023)
- Dynamic Equilibrium of Cardiac Troponin C's Hydrophobic Cleft and Its Modulation by Ca2+ Sensitizers and a Ca2+ Sensitivity Blunting Phosphomimic, cTnT(T204E). Schlecht W, Dong WJ. Bioconjug Chem 28 2581-2590 (2017)
- X-ray structure of a human cardiac muscle troponin C/troponin I chimera in two crystal forms. Yan C, Sack JS. Acta Crystallogr F Struct Biol Commun 78 17-24 (2022)