› 1lv2

X-ray diffraction
2.7Å resolution

Hepatocyte Nuclear Factor 4 is a Transcription Factor that Constitutively Binds Fatty Acids

Released:
DOI: 10.2210/pdb1lv2/pdb
PDB entry 1lv2 coloured by chain, front view.
PDB entry 1lv2 coloured by chain, side view.
PDB entry 1lv2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids.
Wisely GB, Miller AB, Davis RG, Thornquest AD, Johnson R, Spitzer T, Sefler A, Shearer B, Moore JT, Miller AB, Willson TM, Williams SP
Structure 10 1225-34 (2002)
PMID: 12220494

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172026 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepatocyte nuclear factor 4-gamma Chain: A
Molecule details ›
Chain: A
Length: 229 amino acids
Theoretical weight: 25.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14541 (Residues: 103-328; Coverage: 55%)
Gene names: HNF4G, NR2A2
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand PLM 1 x PLM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: I4122
Unit cell:
a: 152.708Å b: 152.708Å c: 93.421Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.247 0.245 0.264
Expression system: Escherichia coli

Quick links

Citations

61 review citations

Nuclear Receptors, RXR, and the Big Bang.
Evans et al. (2014)
60 more

3 mentions without citation

Gain-of-Function Alleles in Caenorhabditis elegans Nuclear Hormone Receptor nhr-49 Are Functionally Distinct.
Lee et al. (2016)
2 more