PDBe 1luf

X-ray diffraction
2.05Å resolution

Crystal Structure of the MuSK Tyrosine Kinase: Insights into Receptor Autoregulation

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Muscle, skeletal receptor tyrosine protein kinase Chain: A
Molecule details ›
Chain: A
Length: 343 amino acids
Theoretical weight: 38.75 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q62838 (Residues: 529-868; Coverage: 40%)
Gene name: Musk
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: I4
Unit cell:
a: 146.939Å b: 146.939Å c: 39.017Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.231 0.231 0.246
Expression system: Spodoptera frugiperda