› 1lr9

X-ray diffraction
2.5Å resolution

STRUCTURE OF Fs1, THE HEPARIN-BINDING DOMAIN OF FOLLISTATIN

Released:
DOI: 10.2210/pdb1lr9/pdb
PDB entry 1lr9 coloured by chain, front view.
PDB entry 1lr9 coloured by chain, side view.
PDB entry 1lr9 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Crystal structures of the heparan sulfate-binding domain of follistatin. Insights into ligand binding.
Innis CA, Hyvönen M
J Biol Chem 278 39969-77 (2003)
PMID: 12867435

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149351 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Follistatin Chain: A
Molecule details ›
Chain: A
Length: 74 amino acids
Theoretical weight: 8.34 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P21674 (Residues: 93-165; Coverage: 23%)
Gene name: Fst
Sequence domains:
Structure domains: Wheat Germ Agglutinin (Isolectin 2); domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P212121
Unit cell:
a: 21.551Å b: 43.733Å c: 77.376Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.22 0.258
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 review citations

Bone morphogenetic protein and growth differentiation factor cytokine families and their protein antagonists.
Rider et al. (2010)
6 more

4 mentions without citation

Structural basis for the inhibition of activin signalling by follistatin.
Harrington et al. (2006)
3 more