› › Function and Biology

High Resolution Structure of Fosfomycin Resistance Protein A (FosA)

Source organism: Pseudomonas aeruginosa
Biochemical function: metal ion binding
Biological process: response to antibiotic
Cellular component: cytoplasm

Quick links

EC 2.5.1.18: Glutathione transferase

Reaction catalysed:
RX + glutathione = HX + R-S-glutathione
Systematic name:
RX:glutathione R-transferase
Alternative Name(s):
  • Glutathione S-alkyl transferase
  • Glutathione S-alkyltransferase
  • Glutathione S-aralkyltransferase
  • Glutathione S-aryltransferase
  • Glutathione S-transferase
  • S-(hydroxyalkyl)glutathione lyase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00903
Domain description: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
Occurring in:
  1. Glutathione transferase FosA
The deposited structure of PDB entry 1lqk contains 2 copies of Pfam domain PF00903 (Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily) in Glutathione transferase FosA. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR029068
Domain description: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
Occurring in:
  1. Glutathione transferase FosA
IPR037523
Domain description: Vicinal oxygen chelate (VOC) domain
Occurring in:
  1. Glutathione transferase FosA
IPR004360
Domain description: Glyoxalase/fosfomycin resistance/dioxygenase domain
Occurring in:
  1. Glutathione transferase FosA

Structure domain

CATH CATH domain
3.10.180.10
Class: Alpha Beta
Architecture: Roll
Topology: 2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1
Homology: 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1
Occurring in:
  1. Glutathione transferase FosA
The deposited structure of PDB entry 1lqk contains 2 copies of CATH domain 3.10.180.10 (2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1) in Glutathione transferase FosA. Showing 1 copy in chain A.
SCOP SCOP annotation
54598
Class: Alpha and beta proteins (a+b)
Fold: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
Superfamily: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
Occurring in:
  1. Glutathione transferase FosA
The deposited structure of PDB entry 1lqk contains 2 copies of SCOP domain 54598 (Antibiotic resistance proteins) in Glutathione transferase FosA. Showing 1 copy in chain A.

Quick links