› 1lq0

X-ray diffraction
2.2Å resolution

CRYSTAL STRUCTURE OF HUMAN CHITOTRIOSIDASE AT 2.2 ANGSTROM RESOLUTION

Released:
DOI: 10.2210/pdb1lq0/pdb
PDB entry 1lq0 coloured by chain, front view.
PDB entry 1lq0 coloured by chain, side view.
PDB entry 1lq0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of human chitotriosidase. Implications for specific inhibitor design and function of mammalian chitinase-like lectins.
Fusetti F, von Moeller H, Houston D, Rozeboom HJ, Dijkstra BW, Boot RG, Aerts JM, van Aalten DM
J Biol Chem 277 25537-44 (2002)
PMID: 11960986

Function and Biology Details

Reaction catalysed: 
Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171609 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chitotriosidase-1 Chain: A
Molecule details ›
Chain: A
Length: 365 amino acids
Theoretical weight: 40.78 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q13231 (Residues: 22-386; Coverage: 82%)
Gene name: CHIT1
Sequence domains: Glycosyl hydrolases family 18
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS
Spacegroup: P43212
Unit cell:
a: 93.45Å b: 93.45Å c: 89.62Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.212 0.248
Expression system: Cricetulus griseus

Quick links

Citations

19 review citations

Exploring the full spectrum of macrophage activation.
Mosser et al. (2008)
18 more

2 mentions without citation

Evolution of mammalian chitinase(-like) members of family 18 glycosyl hydrolases.
Bussink et al. (2007)
1 more