1lo5 Citations

Crystal structure of a SEA variant in complex with MHC class II reveals the ability of SEA to crosslink MHC molecules.

Structure 10 1619-26 (2002)
Cited: 25 times
EuropePMC logo PMID: 12467569

Abstract

Although the biological properties of staphylococcal enterotoxin A (SEA) have been well characterized, structural insights into the interaction between SEA and major histocompatibilty complex (MHC) class II have only been obtained by modeling. Here, the crystal structure of the D227A variant of SEA in complex with human MHC class II has been determined by X-ray crystallography. SEA(D227A) exclusively binds with its N-terminal domain to the alpha chain of HLA-DR1. The ability of one SEA molecule to crosslink two MHC molecules was modeled. It shows that this SEA molecule cannot interact with the T cell receptor (TCR) while a second SEA molecule interacts with MHC. Because of its relatively low toxicity, the D227A variant of SEA is used in tumor therapy.

Articles - 1lo5 mentioned but not cited (4)

  1. Zinc induces dimerization of the class II major histocompatibility complex molecule that leads to cooperative binding to a superantigen. Li H, Zhao Y, Guo Y, Li Z, Eisele L, Mourad W. J. Biol. Chem. 282 5991-6000 (2007)
  2. High affinity of interaction between superantigen and T cell receptor Vbeta molecules induces a high level and prolonged expansion of superantigen-reactive CD4+ T cells. Omoe K, Nunomura W, Kato H, Li ZJ, Igarashi O, Araake M, Sano K, Ono HK, Abe Y, Hu DL, Nakane A, Kiyono H, Takakuwa Y, Shinagawa K, Uchiyama T, Imanishi K. J. Biol. Chem. 285 30427-30435 (2010)
  3. An effective and effecient peptide binding prediction approach for a broad set of HLA-DR molecules based on ordered weighted averaging of binding pocket profiles. Shen WJ, Zhang S, Wong HS. Proteome Sci 11 S15 (2013)
  4. An automated framework for understanding structural variations in the binding grooves of MHC class II molecules. Yeturu K, Utriainen T, Kemp GJ, Chandra N. BMC Bioinformatics 11 Suppl 1 S55 (2010)


Reviews citing this publication (4)

  1. Soluble T cell receptor Vβ domains engineered for high-affinity binding to staphylococcal or streptococcal superantigens. Sharma P, Wang N, Kranz DM. Toxins (Basel) 6 556-574 (2014)
  2. Staphylococcal and streptococcal superantigen exotoxins. Spaulding AR, Salgado-Pabón W, Kohler PL, Horswill AR, Leung DY, Schlievert PM. Clin Microbiol Rev 26 422-447 (2013)
  3. TCR recognition of peptide/MHC class II complexes and superantigens. Sundberg EJ, Deng L, Mariuzza RA. Semin Immunol 19 262-271 (2007)
  4. Interplay between superantigens and immunoreceptors. Petersson K, Forsberg G, Walse B. Scand J Immunol 59 345-355 (2004)

Articles citing this publication (17)

  1. The landscape of human proteins interacting with viruses and other pathogens. Dyer MD, Murali TM, Sobral BW. PLoS Pathog 4 e32 (2008)
  2. Characteristics of carbohydrate antigen binding to the presentation protein HLA-DR. Cobb BA, Kasper DL. Glycobiology 18 707-718 (2008)
  3. A novel loop domain in superantigens extends their T cell receptor recognition site. Günther S, Varma AK, Moza B, Kasper KJ, Wyatt AW, Zhu P, Rahman AK, Li Y, Mariuzza RA, McCormick JK, Sundberg EJ. J Mol Biol 371 210-221 (2007)
  4. Crystal structure of the streptococcal superantigen SpeI and functional role of a novel loop domain in T cell activation by group V superantigens. Brouillard JN, Günther S, Varma AK, Gryski I, Herfst CA, Rahman AK, Leung DY, Schlievert PM, Madrenas J, Sundberg EJ, McCormick JK. J Mol Biol 367 925-934 (2007)
  5. Identification of the antigenic epitopes in staphylococcal enterotoxins A and E and design of a superantigen for human cancer therapy. Erlandsson E, Andersson K, Cavallin A, Nilsson A, Larsson-Lorek U, Niss U, Sjöberg A, Wallén-Ohman M, Antonsson P, Walse B, Forsberg G. J Mol Biol 333 893-905 (2003)
  6. Immunization with a nontoxic mutant of staphylococcal enterotoxin A, SEAD227A, protects against enterotoxin-induced emesis in house musk shrews. Hu DL, Omoe K, Sashinami H, Shinagawa K, Nakane A. J Infect Dis 199 302-310 (2009)
  7. Crystal structure of Mycoplasma arthritidis mitogen complexed with HLA-DR1 reveals a novel superantigen fold and a dimerized superantigen-MHC complex. Zhao Y, Li Z, Drozd SJ, Guo Y, Mourad W, Li H. Structure 12 277-288 (2004)
  8. Staphylococcus aureus enterotoxin C2 mutants: biological activity assay in vitro. Hui J, Cao Y, Xiao F, Zhang J, Li H, Hu F. J Ind Microbiol Biotechnol 35 975-980 (2008)
  9. Persistence of zinc-binding bacterial superantigens at the surface of antigen-presenting cells contributes to the extreme potency of these superantigens as T-cell activators. Pless DD, Ruthel G, Reinke EK, Ulrich RG, Bavari S. Infect Immun 73 5358-5366 (2005)
  10. Superantigen activates the gp130 receptor on adipocytes resulting in altered adipocyte metabolism. Banke E, Rödström K, Ekelund M, Dalla-Riva J, Lagerstedt JO, Nilsson S, Degerman E, Lindkvist-Petersson K, Nilson B. Metabolism 63 831-840 (2014)
  11. The tumor targeted superantigen ABR-217620 selectively engages TRBV7-9 and exploits TCR-pMHC affinity mimicry in mediating T cell cytotoxicity. Hedlund G, Eriksson H, Sundstedt A, Forsberg G, Jakobsen BK, Pumphrey N, Rödström K, Lindkvist-Petersson K, Björk P. PLoS One 8 e79082 (2013)
  12. Structure of Staphylococcal Enterotoxin E in Complex with TCR Defines the Role of TCR Loop Positioning in Superantigen Recognition. Rödström KE, Regenthal P, Lindkvist-Petersson K. PLoS One 10 e0131988 (2015)
  13. Characterization of the Staphylococcal enterotoxin A: Vβ receptor interaction using human receptor fragments engineered for high affinity. Sharma P, Postel S, Sundberg EJ, Kranz DM. Protein Eng Des Sel 26 781-789 (2013)
  14. The superantigen staphylococcal enterotoxin A (SEA) and monoclonal antibody L243 share a common epitope but differ in their ability to induce apoptosis via MHC-II. Gross U, Schroder AK, Haylett RS, Arlt S, Rink L. Immunobiology 211 807-814 (2006)
  15. Thermal stability and structural changes in bacterial toxins responsible for food poisoning. Regenthal P, Hansen JS, André I, Lindkvist-Petersson K. PLoS One 12 e0172445 (2017)
  16. Staphylococcal enterotoxins and enterotoxin-like toxins with special reference to dairy products: An overview. Benkerroum N. Crit Rev Food Sci Nutr 1-28 (2017)
  17. Toxicological and pharmacological assessment of AGEN1884, a novel human IgG1 anti-CTLA-4 antibody. Gombos RB, Gonzalez A, Manrique M, Chand D, Savitsky D, Morin B, Breous-Nystrom E, Dupont C, Ward RA, Mundt C, Duckless B, Tang H, Findeis MA, Schuster A, Waight JD, Underwood D, Clarke C, Ritter G, Merghoub T, Schaer D, Wolchok JD, van Dijk M, Buell JS, Cuillerot JM, Stein R, Drouin EE, Wilson NS. PLoS One 13 e0191926 (2018)