› › Structure analysis

HUMAN P56-LCK TYROSINE KINASE SH2 DOMAIN IN COMPLEX WITH THE PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-GLY (PYEEG PEPTIDE)

X-ray diffraction
1.8Å resolution
PDB entry 1lkl coloured by chain, front view.
PDB entry 1lkl coloured by chain, side view.
PDB entry 1lkl coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Tyrosine-protein kinase Lck and peptide
hide full assembly name
Multimeric state: hetero dimer
Accessible surface area: 6101.53 Å2
Buried surface area: 1014.31 Å2
Dissociation area: 450.63 Å2
Dissociation energy (ΔGdiss): 5.53 kcal/mol
Dissociation entropy (TΔSdiss): 6.02 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138953

Macromolecules

Tyrosine-protein kinase Lck
Chain: A
Length: 104 amino acids
Theoretical weight: 11.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06239 (Residues: 123-226; Coverage: 20%)
Gene name: LCK
Pfam: SH2 domain
InterPro:
CATH: SH2 domain
SCOP: SH2 domain
Tyrosine-protein kinase Lck in PDB entry 1lkl, assembly 1, front view.
Tyrosine-protein kinase Lck in PDB entry 1lkl, assembly 1, side view.
Tyrosine-protein kinase Lck in PDB entry 1lkl, assembly 1, top view.
Molecule details ›

Search similar proteins

PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-GLY
Chain: B
Length: 5 amino acids
Theoretical weight: 602 Da
Source organism: Homo sapiens
Expression system: Not provided
PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-GLY in PDB entry 1lkl, assembly 1, front view.
PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-GLY in PDB entry 1lkl, assembly 1, side view.
PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-GLY in PDB entry 1lkl, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links