› 1lit

X-ray diffraction
1.55Å resolution

HUMAN LITHOSTATHINE

Released:
DOI: 10.2210/pdb1lit/pdb
PDB entry 1lit coloured by chain, front view.
PDB entry 1lit coloured by chain, side view.
PDB entry 1lit coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human lithostathine, the pancreatic inhibitor of stone formation.
Bertrand JA, Pignol D, Bernard JP, Verdier JM, Dagorn JC, Fontecilla-Camps JC
EMBO J 15 2678-84 (1996)
PMID: 8654365

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138672 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lithostathine-1-alpha Chain: A
Molecule details ›
Chain: A
Length: 144 amino acids
Theoretical weight: 16.29 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P05451 (Residues: 23-166; Coverage: 100%)
Gene names: PSPS, PSPS1, REG, REG1A
Sequence domains: Lectin C-type domain
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LURE BEAMLINE DW32
Spacegroup: P65
Unit cell:
a: 47.19Å b: 47.19Å c: 108.66Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.18 0.18 0.24

Quick links

Citations

6 review citations

The C-type lectin-like domain superfamily.
Zelensky et al. (2005)
5 more

13 mentions without citation

Recent advances in the structural mechanisms of DNA glycosylases.
Brooks et al. (2013)
12 more