PDBe 1lcj

X-ray diffraction
1.8Å resolution

SH2 (SRC HOMOLOGY-2) DOMAIN OF HUMAN P56-LCK TYROSINE KINASE COMPLEXED WITH THE 11 RESIDUE PHOSPHOTYROSYL PEPTIDE EPQPYEEIPIYL

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein kinase Lck Chain: A
Molecule details ›
Chain: A
Length: 109 amino acids
Theoretical weight: 12.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06239 (Residues: 119-226; Coverage: 21%)
Gene name: LCK
Sequence domains: SH2 domain
Structure domains: SHC Adaptor Protein
Middle T antigen Chain: B
Molecule details ›
Chain: B
Length: 11 amino acids
Theoretical weight: 1.47 KDa
Source organism: Mesocricetus auratus polyomavirus 1
Expression system: Not provided
UniProt:
  • Canonical: P03079 (Residues: 321-331; Coverage: 3%)

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21212
Unit cell:
a: 61.19Å b: 57.31Å c: 31.18Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.208 not available
Expression systems:
  • Escherichia coli
  • Not provided