PDBe 1lb6

X-ray diffraction
1.8Å resolution

TRAF6-CD40 Complex

Released:

Function and Biology Details

Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)- ubiquitinyl-[acceptor protein]-L-lysine. 
Biochemical function:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tumor necrosis factor receptor superfamily member 5 Chain: B
Molecule details ›
Chain: B
Length: 9 amino acids
Theoretical weight: 1.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P25942 (Residues: 230-238; Coverage: 4%)
Gene names: CD40, TNFRSF5
TNF receptor-associated factor 6 Chain: A
Molecule details ›
Chain: A
Length: 160 amino acids
Theoretical weight: 18.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y4K3 (Residues: 347-504; Coverage: 30%)
Gene names: RNF85, TRAF6
Structure domains: Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P212121
Unit cell:
a: 39.879Å b: 43.815Å c: 101.435Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.203 0.258
Expression system: Escherichia coli