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Bacterial ABC Transporter Involved in B12 Uptake

Source organism: Escherichia coli
Biochemical function: ABC-type vitamin B12 transporter activity
Biological process: transmembrane transport
Cellular component: BtuCD complex

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EC 7.6.2.8: ABC-type vitamin B12 transporter

Reaction catalysed:
ATP + H(2)O + vitamin B12-[cobalamin-binding protein](Side 1) = ADP + phosphate + vitamin B12(Side 2) + [cobalamin-binding protein](Side 1)
Systematic name:
ATP phosphohydrolase (ABC-type, vitamin B12-importing)
Alternative Name(s):
  • BtuCDF
  • Vitamin B12 ABC transporter
  • Vitamin B12-transporting ATPase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00005
Domain description: ABC transporter
Occurring in:
  1. Vitamin B12 import ATP-binding protein BtuD
The deposited structure of PDB entry 1l7v contains 2 copies of Pfam domain PF00005 (ABC transporter) in Vitamin B12 import ATP-binding protein BtuD. Showing 1 copy in chain C.

PF01032
Domain description: FecCD transport family
Occurring in:
  1. Vitamin B12 import system permease protein BtuC
The deposited structure of PDB entry 1l7v contains 2 copies of Pfam domain PF01032 (FecCD transport family) in Vitamin B12 import system permease protein BtuC. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Vitamin B12 import ATP-binding protein BtuD
IPR003439
Domain description: ABC transporter-like, ATP-binding domain
Occurring in:
  1. Vitamin B12 import ATP-binding protein BtuD
IPR000522
Domain description: ABC transporter, permease protein, BtuC-like
Occurring in:
  1. Vitamin B12 import system permease protein BtuC
IPR037294
Domain description: ABC transporter, BtuC-like
Occurring in:
  1. Vitamin B12 import system permease protein BtuC
IPR017871
Domain description: ABC transporter-like, conserved site
Occurring in:
  1. Vitamin B12 import ATP-binding protein BtuD
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. Vitamin B12 import ATP-binding protein BtuD
IPR023693
Domain description: ABC transporter, vitamin B12, BtuD
Occurring in:
  1. Vitamin B12 import ATP-binding protein BtuD
IPR023691
Domain description: ABC transporter, vitamin B12 import, permease protein BtuC
Occurring in:
  1. Vitamin B12 import system permease protein BtuC

Structure domains

CATH CATH domains
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Vitamin B12 import ATP-binding protein BtuD
The deposited structure of PDB entry 1l7v contains 2 copies of CATH domain 3.40.50.300 (Rossmann fold) in Vitamin B12 import ATP-binding protein BtuD. Showing 1 copy in chain C.
1.10.3470.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: ABC transporter involved in vitamin B12 uptake, BtuC
Homology: ABC transporter involved in vitamin B12 uptake, BtuC
Occurring in:
  1. Vitamin B12 import system permease protein BtuC
The deposited structure of PDB entry 1l7v contains 2 copies of CATH domain 1.10.3470.10 (ABC transporter involved in vitamin B12 uptake, BtuC) in Vitamin B12 import system permease protein BtuC. Showing 1 copy in chain A.
SCOP SCOP annotations
52686
Class: Alpha and beta proteins (a/b)
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Occurring in:
  1. Vitamin B12 import ATP-binding protein BtuD
The deposited structure of PDB entry 1l7v contains 2 copies of SCOP domain 52686 (ABC transporter ATPase domain-like) in Vitamin B12 import ATP-binding protein BtuD. Showing 1 copy in chain C.
75648
Class: Membrane and cell surface proteins and peptides
Fold: ABC transporter involved in vitamin B12 uptake, BtuC
Superfamily: ABC transporter involved in vitamin B12 uptake, BtuC
Occurring in:
  1. Vitamin B12 import system permease protein BtuC
The deposited structure of PDB entry 1l7v contains 2 copies of SCOP domain 75648 (ABC transporter involved in vitamin B12 uptake, BtuC) in Vitamin B12 import system permease protein BtuC. Showing 1 copy in chain A.

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