› 1l2e

X-ray diffraction
1.75Å resolution

Human Kallikrein 6 (hK6) Active Form with benzamidine inhibitor

Released:
DOI: 10.2210/pdb1l2e/pdb
PDB entry 1l2e coloured by chain, front view.
PDB entry 1l2e coloured by chain, side view.
PDB entry 1l2e coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in the central nervous system.
Bernett MJ, Blaber SI, Scarisbrick IA, Dhanarajan P, Thompson SM, Blaber M
J Biol Chem 277 24562-70 (2002)
PMID: 11983703

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187789 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kallikrein-6 Chain: A
Molecule details ›
Chain: A
Length: 223 amino acids
Theoretical weight: 24.53 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q92876 (Residues: 22-244; Coverage: 98%)
Gene names: KLK6, PRSS18, PRSS9
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand BEN 1 x BEN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 39.1Å b: 62.08Å c: 85.75Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.209 0.241
Expression system: Spodoptera frugiperda

Quick links

Citations

22 review citations

The emerging roles of human tissue kallikreins in cancer.
Borgoño et al. (2004)
21 more

6 mentions without citation

Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs).
Goettig et al. (2010)
5 more