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Crystal Structure of the 53bp1 BRCT Region Complexed to Tumor Suppressor P53

X-ray diffraction
2.5Å resolution
PDB entry 1kzy coloured by chain, front view.
PDB entry 1kzy coloured by chain, side view.
PDB entry 1kzy coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: TP53-binding protein 1 and Cellular tumor antigen p53
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Multimeric state: hetero tetramer
Accessible surface area: 39867.82 Å2
Buried surface area: 3480.96 Å2
Dissociation area: 1,740.48 Å2
Dissociation energy (ΔGdiss): -23.74 kcal/mol
Dissociation entropy (TΔSdiss): 38.67 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138134

Macromolecules

Cellular tumor antigen p53
Chains: A, B
Length: 195 amino acids
Theoretical weight: 21.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P04637 (Residues: 95-289; Coverage: 50%)
Gene names: P53, TP53
Pfam: P53 DNA-binding domain
InterPro:
CATH: Immunoglobulin-like
SCOP: p53 DNA-binding domain-like
Cellular tumor antigen p53 in PDB entry 1kzy, assembly 1, front view.
Cellular tumor antigen p53 in PDB entry 1kzy, assembly 1, side view.
Cellular tumor antigen p53 in PDB entry 1kzy, assembly 1, top view.
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TP53-binding protein 1
Chains: C, D
Length: 259 amino acids
Theoretical weight: 29.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q12888 (Residues: 1714-1972; Coverage: 13%)
Gene name: TP53BP1
Pfam: BRCA1 C Terminus (BRCT) domain
InterPro:
CATH: BRCT domain
SCOP: 53BP1
TP53-binding protein 1 in PDB entry 1kzy, assembly 1, front view.
TP53-binding protein 1 in PDB entry 1kzy, assembly 1, side view.
TP53-binding protein 1 in PDB entry 1kzy, assembly 1, top view.
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