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CRYSTAL STRUCTURE OF BETA1,3-GLUCURONYLTRANSFERASE I IN COMPLEX WITH THE ACTIVE UDP-GLCUA DONOR

Source organism: Homo sapiens
Biochemical function: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity
Biological process: not assigned
Cellular component: membrane

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EC 2.4.1.135: Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase

Reaction catalysed:
UDP-alpha-D-glucuronate + [protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine = UDP + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine
Systematic name:
UDP-glucuronate:[protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine D-glucuronosyltransferase (configuration-inverting)
Alternative Name(s):
  • Glucuronosyltransferase I
  • UDP-glucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-protein D-glucuronosyltransferase
  • UDP-glucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein D-glucuronosyltransferase
  • Uridine diphosphate glucuronic acid:acceptor glucuronosyltransferase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF03360
Domain description: Glycosyltransferase family 43
Occurring in:
  1. Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3
The deposited structure of PDB entry 1kws contains 2 copies of Pfam domain PF03360 (Glycosyltransferase family 43) in Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR005027
Domain description: Glycosyl transferase, family 43
Occurring in:
  1. Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3
IPR029044
Domain description: Nucleotide-diphospho-sugar transferases
Occurring in:
  1. Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

Structure domain

CATH CATH domain
3.90.550.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Homology: Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Occurring in:
  1. Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3
The deposited structure of PDB entry 1kws contains 2 copies of CATH domain 3.90.550.10 (Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A) in Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3. Showing 1 copy in chain A.
SCOP SCOP annotation
53467
Class: Alpha and beta proteins (a/b)
Fold: Nucleotide-diphospho-sugar transferases
Superfamily: Nucleotide-diphospho-sugar transferases
Occurring in:
  1. Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3
The deposited structure of PDB entry 1kws contains 2 copies of SCOP domain 53467 (1,3-glucuronyltransferase) in Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3. Showing 1 copy in chain A.

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