PDBe 1kn6

Solution NMR

Solution Structure of the Mouse Prohormone Convertase 1 Pro-Domain

Source organism: Mus musculus

Function and Biology Details

Reaction catalysed:
Release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Neuroendocrine convertase 1 Chain: A
Molecule details ›
Chain: A
Length: 90 amino acids
Theoretical weight: 10.67 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P63239 (Residues: 28-110; Coverage: 11%)
Gene names: Att-1, Nec-1, Nec1, Pcsk1
Sequence domains: Peptidase S8 pro-domain
Structure domains: Alpha-Beta Plaits

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 70%
Refinement method: simulated annealing
Chemical shifts: BMR5242  
Expression system: Escherichia coli BL21(DE3)