Function and Biology

Crystal Structure at 1.50 A of an OmpR/PhoB Homolog from Thermotoga maritima

Source organism: Thermotoga maritima
Biochemical function: metal ion binding
Biological process: transcription, DNA-templated
Cellular component: intracellular

Sequence families

Pfam Protein families (Pfam)
PF00072
Domain description: Response regulator receiver domain
Occurring in:
  1. Response regulator
1 copy of Pfam domain PF00072 (Response regulator receiver domain) in Response regulator in PDB 1kgs.

PF00486
Domain description: Transcriptional regulatory protein, C terminal
Occurring in:
  1. Response regulator
1 copy of Pfam domain PF00486 (Transcriptional regulatory protein, C terminal) in Response regulator in PDB 1kgs.

InterPro InterPro annotations
IPR001789
Domain description: Signal transduction response regulator, receiver domain
Occurring in:
  1. Response regulator
IPR001867
Domain description: OmpR/PhoB-type DNA-binding domain
Occurring in:
  1. Response regulator
IPR011006
Domain description: CheY-like superfamily
Occurring in:
  1. Response regulator
IPR036388
Domain description: Winged helix-like DNA-binding domain superfamily
Occurring in:
  1. Response regulator

Structure domains

CATH CATH domains
1.10.10.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Arc Repressor Mutant, subunit A
Homology: "winged helix" repressor DNA binding domain
Occurring in:
  1. Response regulator
1 copy of CATH domain 1.10.10.10 (Arc Repressor Mutant, subunit A) in Response regulator in PDB 1kgs.
3.40.50.2300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Response regulator
1 copy of CATH domain 3.40.50.2300 (Rossmann fold) in Response regulator in PDB 1kgs.
SCOP SCOP annotations
52173
Class: Alpha and beta proteins (a/b)
Fold: Flavodoxin-like
Superfamily: CheY-like
Occurring in:
  1. Response regulator
1 copy of SCOP domain 52173 (CheY-related) in Response regulator in PDB 1kgs.
46895
Class: All alpha proteins
Fold: DNA/RNA-binding 3-helical bundle
Superfamily: C-terminal effector domain of the bipartite response regulators
Occurring in:
  1. Response regulator
1 copy of SCOP domain 46895 (PhoB-like) in Response regulator in PDB 1kgs.