Structure analysis

Structure of the Epstein-Barr Virus gp42 Protein Bound to the MHC class II Receptor HLA-DR1

X-ray diffraction
2.65Å resolution
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 25000 Å2
Buried surface area: 8400 Å2
Dissociation area: 500 Å2
Dissociation energy (ΔGdiss): -9 kcal/mol
Dissociation entropy (TΔSdiss): 12 kcal/mol
Interface energy (ΔGint): -37 kcal/mol
Symmetry number: 1

Macromolecules

Chain: C
Length: 136 amino acids
Theoretical weight: 15.63 KDa
Source organism: Human gammaherpesvirus 4
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P03205 (Residues: 86-221; Coverage: 61%)
Gene name: BZLF2
InterPro:
CATH: Mannose-Binding Protein A, subunit A
SCOP: C-type lectin domain

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Chain: D
Length: 13 amino acids
Theoretical weight: 1.51 KDa
Source organism: synthetic construct
Expression system: Not provided
UniProt:
  • Canonical: P03437 (Residues: 322-334; Coverage: 2%)
Gene name: HA

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