PDBe 1ken

X-ray diffraction
3.5Å resolution

INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH AN ANTIBODY THAT PREVENTS THE HEMAGGLUTININ LOW PH FUSOGENIC TRANSITION

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero decamer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Hemagglutinin HA1 chain Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 328 amino acids
Theoretical weight: 36.07 KDa
Source organism: Influenza A virus (A/X-31(H3N2))
UniProt:
  • Canonical: P03438 (Residues: 17-344; Coverage: 60%)
Gene name: HA
Structure domains: Hemagglutinin (Ha1 Chain); Chain: A; domain 1
Hemagglutinin HA2 chain Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 175 amino acids
Theoretical weight: 20.21 KDa
Source organism: Influenza A virus (A/X-31(H3N2))
UniProt:
  • Canonical: P03437 (Residues: 346-520; Coverage: 32%)
Gene name: HA
Structure domains: Hemagglutinin Ectodomain; Chain B
Ig gamma-1 chain C region, membrane-bound form Chains: H, T
Molecule details ›
Chains: H, T
Length: 221 amino acids
Theoretical weight: 24.35 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P01869 (Residues: 1-101; Coverage: 26%)
Gene names: Igh-4, Ighg1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Ig kappa chain C region Chains: L, U
Molecule details ›
Chains: L, U
Length: 213 amino acids
Theoretical weight: 23.28 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P01837 (Residues: 1-104; Coverage: 98%)
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: P21212
Unit cell:
a: 143.041Å b: 315.588Å c: 97.029Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.255 0.255 0.323