Function and Biology

X-RAY CRYSTAL STRUCTURE OF HUMAN CERULOPLASMIN AT 3.0 ANGSTROMS

Source organism: Homo sapiens
Biochemical function: protein-folding chaperone binding
Biological process: cellular oxidant detoxification
Cellular component: blood microparticle

EC 1.16.3.1: Ferroxidase

Reaction catalysed:
4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O
Systematic name:
Fe(II):oxygen oxidoreductase
Alternative Name(s):
  • Caeruloplasmin
  • Ceruloplasmin
  • Ferro:O(2) oxidoreductase
  • Ferroxidase I
  • HEPH
  • Hephaestin
  • Iron II:oxygen oxidoreductase
  • Iron oxidase
  • Iron(II):oxygen oxidoreductase

Sequence families

Pfam Protein families (Pfam)
PF07732
Domain description: Multicopper oxidase
Occurring in:
  1. Ceruloplasmin
The deposited structure of PDB entry 1kcw contains 2 copies of Pfam domain PF07732 (Multicopper oxidase) in Ceruloplasmin. Showing 2 copies in chain A.

PF07731
Domain description: Multicopper oxidase
Occurring in:
  1. Ceruloplasmin
The deposited structure of PDB entry 1kcw contains 1 copy of Pfam domain PF07731 (Multicopper oxidase) in Ceruloplasmin. Showing 1 copy in chain A.

PF00394
Domain description: Multicopper oxidase
Occurring in:
  1. Ceruloplasmin
The deposited structure of PDB entry 1kcw contains 1 copy of Pfam domain PF00394 (Multicopper oxidase) in Ceruloplasmin. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR008972
Domain description: Cupredoxin
Occurring in:
  1. Ceruloplasmin
IPR033138
Domain description: Multicopper oxidases, conserved site
Occurring in:
  1. Ceruloplasmin
IPR011707
Domain description: Multicopper oxidase-like, N-terminal
Occurring in:
  1. Ceruloplasmin
IPR002355
Domain description: Multicopper oxidase, copper-binding site
Occurring in:
  1. Ceruloplasmin
IPR011706
Domain description: Multicopper oxidase, C-terminal
Occurring in:
  1. Ceruloplasmin
IPR048236
Domain description: Ceruloplasmin-like, fifth cupredoxin domain
Occurring in:
  1. Ceruloplasmin
IPR001117
Domain description: Multicopper oxidase, second cupredoxin domain
Occurring in:
  1. Ceruloplasmin
IPR045087
Domain description: Multicopper oxidase
Occurring in:
  1. Ceruloplasmin

Structure domain

CATH CATH domain
2.60.40.420
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Cupredoxins - blue copper proteins
Occurring in:
  1. Ceruloplasmin
The deposited structure of PDB entry 1kcw contains 6 copies of CATH domain 2.60.40.420 (Immunoglobulin-like) in Ceruloplasmin. Showing 6 copies in chain A.
SCOP SCOP annotation
49550
Class: All beta proteins
Fold: Cupredoxin-like
Superfamily: Cupredoxins
Occurring in:
  1. Ceruloplasmin
The deposited structure of PDB entry 1kcw contains 6 copies of SCOP domain 49550 (Multidomain cupredoxins) in Ceruloplasmin. Showing 6 copies in chain A.