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L-HISTIDINOL DEHYDROGENASE (HISD) STRUCTURE COMPLEXED WITH L-HISTIDINOL (SUBSTRATE), ZINC AND NAD (COFACTOR)

X-ray diffraction
1.7Å resolution
PDB entry 1kae coloured by chain, front view.
PDB entry 1kae coloured by chain, side view.
PDB entry 1kae coloured by chain, top view.
Source organism: Escherichia coli
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Histidinol dehydrogenase
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Multimeric state: homo dimer
Accessible surface area: 32846.3 Å2
Buried surface area: 14271.59 Å2
Dissociation area: 5,199.46 Å2
Dissociation energy (ΔGdiss): 95.38 kcal/mol
Dissociation entropy (TΔSdiss): 15.81 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-139324

Macromolecules

Histidinol dehydrogenase
Chains: A, B
Length: 434 amino acids
Theoretical weight: 46.48 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P06988 (Residues: 1-434; Coverage: 100%)
Gene names: JW2002, b2020, hisD
Pfam: Histidinol dehydrogenase
InterPro:
CATH:
SCOP: L-histidinol dehydrogenase HisD
Histidinol dehydrogenase in PDB entry 1kae, assembly 1, front view.
Histidinol dehydrogenase in PDB entry 1kae, assembly 1, side view.
Histidinol dehydrogenase in PDB entry 1kae, assembly 1, top view.
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