PDBe 1k7l

X-ray diffraction
2.5Å resolution

The 2.5 Angstrom resolution crystal structure of the human PPARalpha ligand binding domain bound with GW409544 and a co-activator peptide.

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nuclear receptor coactivator 1 Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 21 amino acids
Theoretical weight: 2.43 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15788 (Residues: 680-700; Coverage: 2%)
Gene names: BHLHE74, NCOA1, SRC1
Peroxisome proliferator-activated receptor alpha Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 288 amino acids
Theoretical weight: 32.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07869 (Residues: 192-468; Coverage: 59%)
Gene names: NR1C1, PPAR, PPARA
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 95.561Å b: 121.597Å c: 121.994Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.247 0.247 0.284
Expression systems:
  • Not provided
  • Escherichia coli