PDBe 1k4w

X-ray diffraction
1.9Å resolution

X-ray structure of the orphan nuclear receptor ROR beta ligand-binding domain in the active conformation

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nuclear receptor ROR-beta Chain: A
Molecule details ›
Chain: A
Length: 252 amino acids
Theoretical weight: 28.9 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P45446 (Residues: 212-463; Coverage: 54%)
Gene names: Nr1f2, Rorb, Rzrb
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 1 Chain: B
Molecule details ›
Chain: B
Length: 15 amino acids
Theoretical weight: 1.78 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15788 (Residues: 686-700; Coverage: 1%)
Gene names: BHLHE74, NCOA1, SRC1

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-3
Spacegroup: P212121
Unit cell:
a: 52.302Å b: 58.489Å c: 106.036Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.224 0.249
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided