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Crystal Structure of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase

Source organism: Homo sapiens
Biochemical function: protein tyrosine kinase activity
Biological process: signal complex assembly
Cellular component: focal adhesion

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EC 2.7.10.2: Non-specific protein-tyrosine kinase

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Systematic name:
ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
Alternative Name(s):
  • ABL
  • ABL1
  • ABL2
  • ABLL
  • ACK1
  • ACK2
  • AGMX1
  • ARG
  • ATK
  • ATP:protein-tyrosine O-phosphotransferase
  • BLK
  • BMX
  • BRK
  • BTK
  • BTKL
  • Bmk
  • Bruton's tyrosine kinase
  • Bsk
  • CAKb
  • CHK
  • CSK
  • CTK
  • CYL
  • Cdgip
  • Cytoplasmic protein tyrosine kinase
  • EMT
  • ETK
  • FAK
  • FAK2
  • FER
  • FES
  • FGR
  • FPS
  • FRK
  • FYN
  • Fadk
  • Fert1/2
  • Focal adhesion kinase
  • HCK
  • HCTK
  • HYL
  • IMD1
  • ITK
  • IYK
  • JAK1
  • JAK2
  • JAK3
  • JTK1
  • JTK9
  • Janus kinase 1
  • Janus kinase 2
  • Janus kinase 3
  • L-JAK
  • LCK
  • LSK
  • LYN
  • MATK
  • Ntk
  • P60c-src protein tyrosine kinase
  • PKB
  • PSCTK
  • PSCTK1
  • PSCTK2
  • PSCTK4
  • PSCTK5
  • PTK2
  • PTK2B
  • PTK6
  • PYK2
  • Protein-tyrosine kinase
  • RAFTK
  • RAK
  • Rlk
  • SLK
  • SRC
  • SRC2
  • SRK
  • SRM
  • SRMS
  • STD
  • SYK
  • SYN
  • Sik
  • TEC
  • TNK1
  • TXK
  • TYK2
  • TYK3
  • Tck
  • Tsk
  • YES1
  • YK2
  • ZAP70

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF03623
Domain description: Focal adhesion targeting region
Occurring in:
  1. Focal adhesion kinase 1
The deposited structure of PDB entry 1k04 contains 1 copy of Pfam domain PF03623 (Focal adhesion targeting region) in Focal adhesion kinase 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR005189
Domain description: Focal adhesion kinase, targeting (FAT) domain
Occurring in:
  1. Focal adhesion kinase 1
IPR036137
Domain description: Focal adhesion kinase, targeting (FAT) domain superfamily
Occurring in:
  1. Focal adhesion kinase 1

Structure domains

CATH CATH domains
1.20.120.330
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Four Helix Bundle (Hemerythrin (Met), subunit A)
Homology: Nucleotidyltransferases domain 2
Occurring in:
  1. Focal adhesion kinase 1
The deposited structure of PDB entry 1k04 contains 1 copy of CATH domain 1.20.120.330 (Four Helix Bundle (Hemerythrin (Met), subunit A)) in Focal adhesion kinase 1. Showing 1 copy in chain A.
1.20.5.540
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homology: Single helix bin
Occurring in:
  1. Focal adhesion kinase 1
The deposited structure of PDB entry 1k04 contains 1 copy of CATH domain 1.20.5.540 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in Focal adhesion kinase 1. Showing 1 copy in chain A.
SCOP SCOP annotation
68994
Class: All alpha proteins
Fold: Four-helical up-and-down bundle
Superfamily: FAT domain of focal adhesion kinase
Occurring in:
  1. Focal adhesion kinase 1
The deposited structure of PDB entry 1k04 contains 1 copy of SCOP domain 68994 (FAT domain of focal adhesion kinase) in Focal adhesion kinase 1. Showing 1 copy in chain A.

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