Structure analysis

Xray Structure of Grb2 SH2 Domain

X-ray diffraction
2.75Å resolution
Source organism: Homo sapiens
Assemblies composition:
monomeric (preferred)
homo octamer
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric

Binding statistics and energies are not available for this assembly
Assembly 2
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Multimeric state: homo octamer
Accessible surface area: 36100 Å2
Buried surface area: 27000 Å2
Dissociation area: 4,300 Å2
Dissociation energy (ΔGdiss): 25 kcal/mol
Dissociation entropy (TΔSdiss): 39 kcal/mol
Interface energy (ΔGint): -179 kcal/mol
Symmetry number: 8

Macromolecules

Chain: A
Length: 96 amino acids
Theoretical weight: 11.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62993 (Residues: 60-151; Coverage: 42%)
Gene names: ASH, GRB2
Pfam: SH2 domain
InterPro: SH2 domain
CATH: SHC Adaptor Protein
SCOP: SH2 domain

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