PDBe 1jyr

X-ray diffraction
1.55Å resolution

Xray Structure of Grb2 SH2 Domain Complexed with a Phosphorylated Peptide

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
peptide: PSpYVNVQN Chain: L
Molecule details ›
Chain: L
Length: 9 amino acids
Theoretical weight: 1.07 KDa
Source organism: Synthetic construct
Expression system: Not provided
Growth factor receptor-bound protein 2 Chain: A
Molecule details ›
Chain: A
Length: 96 amino acids
Theoretical weight: 11.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62993 (Residues: 60-151; Coverage: 42%)
Gene names: ASH, GRB2
Sequence domains: SH2 domain
Structure domains: SHC Adaptor Protein

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X31
Spacegroup: P41212
Unit cell:
a: 50.8Å b: 50.8Å c: 89.44Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.19 0.228
Expression systems:
  • Not provided
  • Escherichia coli