PDBe 1jyq

X-ray diffraction
2Å resolution

Xray Structure of Grb2 SH2 Domain Complexed with a Highly Affine Phospho Peptide


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
hetero tetramer (preferred)
hetero octamer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Growth factor receptor-bound protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 96 amino acids
Theoretical weight: 11.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P62993 (Residues: 60-151; Coverage: 42%)
Gene names: ASH, GRB2
Sequence domains: SH2 domain
Structure domains: SHC Adaptor Protein
mAZ-pY-(alpha Me)pY-N-NH2 peptide inhibitor Chains: H, L
Molecule details ›
Chains: H, L
Length: 4 amino acids
Theoretical weight: 766 Da
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands

2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE
Spacegroup: P6122
Unit cell:
a: 60.999Å b: 60.999Å c: 177.046Å
α: 90° β: 90° γ: 120°
R R work R free
0.185 0.185 0.251
Expression systems:
  • Escherichia coli
  • Not provided