PDBe 1jwh

X-ray diffraction
3.1Å resolution

Crystal Structure of Human Protein Kinase CK2 Holoenzyme

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Casein kinase II subunit beta Chains: C, D
Molecule details ›
Chains: C, D
Length: 215 amino acids
Theoretical weight: 24.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Best match: P67870 (Residues: 1-215)
Gene names: CK2N, CSNK2B, G5A
Casein kinase II subunit alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 337 amino acids
Theoretical weight: 40.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Best match: P68400 (Residues: 1-337)
Gene names: CK2A1, CSNK2A1

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7B
Spacegroup: P63
Unit cell:
a: 175.99Å b: 175.99Å c: 93.666Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.267 0.267 0.338
Expression system: Escherichia coli